Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8993429 | 0.69 | PTGS2 (0.30) | PTGS2 | |
| SCHEMBL8993563 | 0.67 | PTGS2 (0.35) | PTGS2 | |
| SCHEMBL15074480 | 0.60 | GLP1R (0.38) | LRRK2PTGS2 | |
| SCHEMBL30254246 | 0.59 | GLP1R (0.37) | LRRK2PTGS2 | |
| SCHEMBL15052853 | 0.59 | GLP1R (0.37) | LRRK2PTGS2 | |
| SCHEMBL22077205 | 0.58 | TRPV1 (0.40) | LRRK2PDE3BPDE3A | |
| SCHEMBL31435340 | 0.58 | PIK3R1 (0.37) | LRRK2CDK2KDRPDE3BPDE3A | |
| SCHEMBL31435349 | 0.57 | PDE3B (0.40) | PDE3BPDE3A | |
| SCHEMBL31435315 | 0.57 | CSF1R (0.36) | PDE3BPDE3A | |
| SCHEMBL8338246 | 0.57 | ASPH (0.41) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0724566-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-08-07 | — | — | EP | disclosed |
| WO-1995011883-A1 | 1,2-DIARYLCYCLOPENTENYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-05-04 | — | — | WO | disclosed |