SCHEMBL8993535

SCHEMBL8993535

CCS(=O)(=O)c1ccc(C(=O)O)c(Cl)c1OCCOC

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 2/20 0.45
CYP1A2 P05177 1/20 0.45
CYP3A4 P08684 1/20 0.45
CYP2D6 P10635 1/20 0.45
CYP2C9 P11712 1/20 0.45
HPGD P15428 1/20 0.45
CYP2C19 P33261 1/20 0.45
ATM Q13315 1/20 0.45
ALDH1A1 P00352 2/20 0.41
HTT P42858 2/20 0.39
MEN1 O00255 1/20 0.39
LMNA P02545 1/20 0.39
KMT2A Q03164 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
IKBKB O14920 1/20 0.38
PRKAB2 O43741 1/20 0.36
PRKAG1 P54619 1/20 0.36
PRKAA2 P54646 1/20 0.36
PRKAA1 Q13131 1/20 0.36
PRKAG3 Q9UGI9 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7976218 0.88 PRKAB2 (0.37) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9709898 0.86 IKBKB (0.49) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8993468 0.86 IKBKB (0.42) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL6564104 0.85 MAPT (0.47) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9194829 0.84 MAPT (0.37) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL6152062 0.83 MAPT (0.43) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL24886361 0.82 ALDH1A1 (0.37) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL28557666 0.81 CYP1A2 (0.41) MAPTCYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL8993574 0.80 ALDH1A1 (0.44) MAPTHPGDALDH1A1KMT2APRKAB2
SCHEMBL3255428 0.79 NPC1 (0.44) MAPTCYP1A2CYP3A4CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0369803-B2 Trisubstituted benzoic acid intermediates ZENECA INC (US) 1996-08-14 EP disclosed
EP-0444152-B1 CERTAIN 2-(2',3',4'-TRISUBSTITUTED BENZOYL)-1,3-CYCLOHEXANEDIONES ZENECA INC (US) 1995-06-14 EP disclosed
EP-0444143-B1 TRISUBSTITUTED BENZOIC ACID INTERMEDIATES ZENECA INC (US) 1994-11-30 EP disclosed
US-5075497-A Chemical intermediate for 2-(2,3,4-trisubstitutedbenzoyl)-1,3-cyclohexanedione ICI AMERICAS, INC. (US) 1991-12-24 US disclosed
US-5073642-A Trisubstituted benzoic acid intermediates ICI AMERICAS INC. (US) 1991-12-17 US disclosed
US-5068423-A Intermediates for herbicides 2-(2,3,4-trisubstituted benzoyl)-1,3-cyclohexanediones ICI AMERICAS INC. (US) 1991-11-26 US disclosed
US-5047572-A For 2-*2,3,4-trisubstituted benzoyl)-1,3-cyclohexanedione ICI AMERICAS INC. (US) 1991-09-10 US disclosed
EP-0444152-A1 CERTAIN 2-(2',3',4'-TRISUBSTITUTED BENZOYL)-1,3-CYCLOHEXANEDIONES. ICI AMERICA INC (US) 1991-09-04 EP disclosed
EP-0444143-A1 TRISUBSTITUTED BENZOIC ACID INTERMEDIATES. ICI AMERICA INC (US) 1991-09-04 EP disclosed
US-5001256-A Trisubstituted benzoic acid intermediates ICI AMERICAS INC. (US) 1991-03-19 US disclosed
US-4957538-A HERBICIDES ICI AMERICAS INC. (US) 1990-09-18 US disclosed
WO-1990005712-A1 CERTAIN 2-(2',3',4'-TRISUBSTITUTED BENZOYL)-1,3-CYCLOHEXANEDIONES ICI AMERICAS INC. (US) 1990-05-31 WO disclosed
WO-1990005715-A1 TRISUBSTITUTED BENZOIC ACID INTERMEDIATES ICI AMERICAS INC. (US) 1990-05-31 WO disclosed
EP-0369803-A1 Trisubstituted benzoic acid intermediates ZENECA INC. (US) 1990-05-23 EP disclosed