⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13640032 | 0.77 | CYP1A2 (0.33) | — | |
| SCHEMBL1030996 | 0.75 | CYP1A2 (0.37) | — | |
| SCHEMBL14490868 | 0.73 | PIK3CD (0.30) | — | |
| SCHEMBL18799828 | 0.73 | KDM4E (0.39) | — | |
| SCHEMBL55948 | 0.72 | ALDH1A1 (0.46) | — | |
| SCHEMBL3285306 | 0.71 | — | — | |
| SCHEMBL247607 | 0.71 | ARG1 (0.35) | — | |
| Hydrochloric Acid SCHEMBL55994 | 0.70 | ALDH1A1 (0.44) | — | |
| Hydrochloric Acid SCHEMBL6150114 | 0.70 | ARG1 (0.34) | — | |
| SCHEMBL27461329 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129411-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-8129411-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| EP-2420491-A1 | 3 , 5-substitued piperidine compounds as renin inhibitors | Novartis AG (CH) | 2012-02-22 | — | — | EP | disclosed |
| US-20090192148-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-07-30 | — | — | US | disclosed |
| US-20090192148-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-07-30 | — | — | US | disclosed |
| WO-2007077005-A1 | 3 , 5-SUBSTITΓUED PIPERIDINE COMPOUNDS AS RENIN INHIBITORS | NOVARTIS AG (CH) | 2007-07-12 | — | — | WO | disclosed |