Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 5/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.82 |
| ▸ | EYA3 | Q99504 | 3/20 | 0.71 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | HPGD | P15428 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | KDM7A | Q6ZMT4 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 1/20 | 0.58 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CNR2 | P34972 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9316490 | 0.85 | CYP2C19 (0.73) | CYP2C19CYP2C9EYA3L3MBTL1KDM4E | |
| SCHEMBL28245012 | 0.84 | CYP2C19 (0.79) | CYP2C19CYP2C9EYA3L3MBTL1TDP1 | |
| SCHEMBL28245008 | 0.84 | CYP2C19 (0.79) | CYP2C19CYP2C9EYA3L3MBTL1MAPT | |
| SCHEMBL8994710 | 0.83 | CYP2C19 (1.00) | CYP2C19CYP2C9EYA3KDM7AHTT | |
| SCHEMBL9444836 | 0.82 | CYP2C19 (0.70) | CYP2C19CYP2C9EYA3L3MBTL1MAPT | |
| SCHEMBL28245013 | 0.82 | CYP2C19 (0.75) | CYP2C19CYP2C9EYA3L3MBTL1MAPT | |
| SCHEMBL11673920 | 0.82 | L3MBTL1 (0.92) | CYP2C19L3MBTL1NPC1ATMCNR2 | |
| SCHEMBL1287462 | 0.82 | CYP2C9 (0.83) | CYP2C19CYP2C9EYA3L3MBTL1TDP1 | |
| SCHEMBL11736681 | 0.81 | L3MBTL1 (0.90) | CYP2C19CYP2C9L3MBTL1NPC1ALDH1A1 | |
| SCHEMBL11671790 | 0.81 | L3MBTL1 (0.90) | CYP2C19CYP2C9L3MBTL1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585404-A | ANTIARRHYTHMIA AGENT | KARO BIO AB (SE) | 1996-12-17 | — | — | US | disclosed |
| US-5567728-A | BENZOYL BENZOFURAN DERIVATIVES USED TO PREVENT OR TREAT CARDIAC ARRHYTHMIA | KAROBIO AKTIEBOLAG (SE) | 1996-10-22 | — | — | US | disclosed |
| EP-0584186-B1 | RECEPTOR LIGANDS | KAROBIO AB (SE) | 1996-08-21 | — | — | EP | disclosed |
| EP-0584186-A1 | RECEPTOR LIGANDS. | KAROBIO AB (SE) | 1994-03-02 | — | — | EP | disclosed |
| WO-1992020331-A1 | RECEPTOR LIGANDS | KAROBIO AKTIEBOLAG (SE) | 1992-11-26 | — | — | WO | disclosed |
| US-3983245-A | CORONARY VASODILATORS | SMITHKLINE CORPORATION (US) | 1976-09-28 | — | — | US | disclosed |
| US-3975537-A | SUBSTITUTED BENZOFURANS | SMITH KLINE (US) | 1976-08-17 | — | — | US | disclosed |