Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VKORC1 | Q9BQB6 | 2/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 3/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.49 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL984055 | 0.78 | LTA4H (0.67) | VKORC1MAOBLTA4HMEN1KMT2A | |
| SCHEMBL8934551 | 0.77 | VKORC1 (0.66) | VKORC1MAOBCA2KDM4EALDH1A1 | |
| SCHEMBL11734282 | 0.75 | VKORC1 (0.54) | VKORC1CYP2C19CYP2C9MEN1KMT2A | |
| SCHEMBL15046894 | 0.74 | KDM4E (0.50) | CYP2C19THRBTHRACYP2C9MEN1 | |
| SCHEMBL28316267 | 0.72 | CYP11B1 (0.64) | VKORC1MAOBTHRBRAB9ANPC1 | |
| SCHEMBL8183283 | 0.71 | CA2 (0.54) | CYP2C19THRBTHRACYP2C9CA2 | |
| SCHEMBL11729224 | 0.71 | MAOB (0.79) | VKORC1MAOBLTA4HCA2MAPT | |
| SCHEMBL1253476 | 0.70 | CA2 (0.62) | CYP2C19THRBTHRACYP2C9MEN1 | |
| SCHEMBL8283495 | 0.70 | CA2 (0.47) | CYP2C19THRBTHRAMEN1KMT2A | |
| SCHEMBL3084454 | 0.70 | MAOB (0.50) | VKORC1MAOBLTA4HALOX5MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585404-A | ANTIARRHYTHMIA AGENT | KARO BIO AB (SE) | 1996-12-17 | — | — | US | disclosed |
| US-5567728-A | BENZOYL BENZOFURAN DERIVATIVES USED TO PREVENT OR TREAT CARDIAC ARRHYTHMIA | KAROBIO AKTIEBOLAG (SE) | 1996-10-22 | — | — | US | disclosed |
| EP-0584186-B1 | RECEPTOR LIGANDS | KAROBIO AB (SE) | 1996-08-21 | — | — | EP | disclosed |
| EP-0584186-A1 | RECEPTOR LIGANDS. | KAROBIO AB (SE) | 1994-03-02 | — | — | EP | disclosed |
| WO-1992020331-A1 | RECEPTOR LIGANDS | KAROBIO AKTIEBOLAG (SE) | 1992-11-26 | — | — | WO | disclosed |