Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8994946 | 0.88 | LTB4R (0.58) | HRH3HPGDHSD17B10L3MBTL1LTB4R | |
| SCHEMBL8995063 | 0.86 | HPGD (0.65) | HPGDHSD17B10L3MBTL1LTB4RALDH1A1 | |
| SCHEMBL8994972 | 0.86 | HPGD (0.64) | HPGDHSD17B10L3MBTL1LTB4RALDH1A1 | |
| Hydrochloric Acid SCHEMBL8994953 | 0.81 | HRH3 (0.46) | HRH3HPGDHSD17B10L3MBTL1LTB4R | |
| SCHEMBL8994910 | 0.80 | LTB4R (0.55) | HPGDLTB4RALDH1A1PLA2G4BTSHR | |
| SCHEMBL8994906 | 0.77 | LTB4R (0.53) | LTB4RPLA2G4BMEN1TSHRKMT2A | |
| SCHEMBL8994912 | 0.77 | LTB4R (0.59) | LTB4RPLA2G4BTSHRPOLBLTB4R2 | |
| SCHEMBL8994887 | 0.76 | LTB4R (0.76) | LTB4RPLA2G4BTSHRPOLBLTB4R2 | |
| SCHEMBL8995032 | 0.76 | SMPD1 (0.51) | HRH3L3MBTL1LTB4RPLA2G4BMEN1 | |
| SCHEMBL18574518 | 0.76 | ROCK2 (0.49) | HPGDHSD17B10L3MBTL1ALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |
| EP-0518819-A2 | Amidino compounds, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |