Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.48 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994972 | 0.99 | HPGD (0.64) | HPGDHSD17B10L3MBTL1ALDH1A1POLB | |
| SCHEMBL8994859 | 0.86 | HRH3 (0.48) | HPGDHSD17B10L3MBTL1ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL8995012 | 0.86 | HPGD (0.64) | HPGDHSD17B10L3MBTL1ALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL8995064 | 0.85 | HPGD (0.63) | HPGDHSD17B10L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL8994906 | 0.83 | LTB4R (0.53) | MEN1KMT2ALTB4RPLA2G4BMAPT | |
| SCHEMBL8994912 | 0.82 | LTB4R (0.59) | POLBLTB4RPLA2G4BMAPTPRSS1 | |
| SCHEMBL8995032 | 0.81 | SMPD1 (0.51) | L3MBTL1MEN1KMT2ATP53LTB4R | |
| SCHEMBL8994910 | 0.79 | LTB4R (0.55) | HPGDALDH1A1POLBTP53NPSR1 | |
| SCHEMBL8995031 | 0.79 | LTB4R (0.56) | LTB4RPLA2G4BMAPTPRSS1 | |
| SCHEMBL8994887 | 0.79 | LTB4R (0.76) | POLBLTB4RPLA2G4BMAPTPRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |
| EP-0518819-A2 | Amidino compounds, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |