Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.72 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.66 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.46 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994895 | 1.00 | LTB4R (0.72) | LTB4RLTB4R2PLA2G4BPRSS1MAPT | |
| SCHEMBL8994891 | 0.90 | LTB4R (0.75) | LTB4RLTB4R2PLA2G4BPRSS1MAPT | |
| SCHEMBL8994930 | 0.90 | LTB4R (0.75) | LTB4RLTB4R2PLA2G4BPRSS1MAPT | |
| SCHEMBL8994880 | 0.90 | LTB4R (0.74) | LTB4RLTB4R2PLA2G4BPRSS1MAPT | |
| SCHEMBL8747955 | 0.88 | LTB4R (0.78) | LTB4RLTB4R2PLA2G4BPRSS1MAPT | |
| SCHEMBL8747956 | 0.88 | LTB4R (0.78) | LTB4RLTB4R2PLA2G4BPRSS1MAPT | |
| SCHEMBL8748241 | 0.88 | LTB4R (0.78) | LTB4RLTB4R2PLA2G4BPRSS1MAPT | |
| SCHEMBL8748238 | 0.88 | LTB4R (0.78) | LTB4RLTB4R2PLA2G4BPRSS1MAPT | |
| SCHEMBL8994848 | 0.88 | LTB4R (0.53) | LTB4RLTB4R2PLA2G4BMAPTTSHR | |
| SCHEMBL8994846 | 0.88 | LTB4R (0.53) | LTB4RLTB4R2PLA2G4BMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |