Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.72 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.64 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.52 |
| ▸ | THRA | P10827 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.47 |
| ▸ | REN | P00797 | 4/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8203909 | 0.90 | LTB4R (0.69) | LTB4RLTB4R2PRSS1THRATHRB | |
| SCHEMBL8074983 | 0.89 | LTB4R (0.67) | LTB4RLTB4R2PRSS1THRATHRB | |
| SCHEMBL6138115 | 0.86 | LTB4R (0.74) | LTB4RLTB4R2TSHRBCL2L1REN | |
| SCHEMBL8994928 | 0.86 | LTB4R (0.84) | LTB4RLTB4R2PRSS1THRATHRB | |
| SCHEMBL8748091 | 0.84 | LTB4R (0.74) | LTB4RLTB4R2PRSS1THRATHRB | |
| Moxilubant SCHEMBL6439215 | 0.84 | LTB4R (1.00) | LTB4RLTB4R2PRSS1HTR2AADRA1A | |
| SCHEMBL8747939 | 0.84 | LTB4R (0.74) | LTB4RLTB4R2PRSS1THRATHRB | |
| Moxilubant SCHEMBL29388138 | 0.84 | LTB4R (1.00) | LTB4RLTB4R2PRSS1HTR2AADRA1A | |
| Moxilubant SCHEMBL8994884 | 0.83 | LTB4R (0.98) | LTB4RLTB4R2PRSS1HTR2AADRA1A | |
| SCHEMBL8748088 | 0.83 | LTB4R (0.72) | LTB4RLTB4R2PRSS1THRATHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |