Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.63 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.45 |
| ▸ | GMNN | O75496 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7711975 | 0.93 | LTB4R (0.72) | LTB4RLTB4R2LMNAALDH1A1POLB | |
| SCHEMBL8994985 | 0.92 | LTB4R (0.68) | LTB4RLTB4R2LMNAALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL8994890 | 0.92 | LTB4R (0.71) | LTB4RLTB4R2LMNAALDH1A1POLB | |
| SCHEMBL9702013 | 0.90 | LTB4R (0.68) | LTB4RLTB4R2LMNAALDH1A1POLB | |
| Fumaric Acid SCHEMBL3182319 | 0.89 | LTB4R (0.76) | LTB4RLTB4R2LMNAALDH1A1POLB | |
| Maleic Acid SCHEMBL7748813 | 0.89 | LTB4R (0.76) | LTB4RLTB4R2LMNAALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL8995021 | 0.89 | LTB4R (0.68) | LTB4RLTB4R2MAPTPLA2G4BPRSS1 | |
| Moxilubant SCHEMBL8994961 | 0.87 | LTB4R (0.84) | LTB4RLTB4R2LMNAALDH1A1POLB | |
| SCHEMBL9699613 | 0.84 | LTB4R (0.59) | LTB4RLTB4R2LMNAALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL9701722 | 0.83 | LTB4R (0.58) | LTB4RLTB4R2LMNAALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |
| EP-0518819-A2 | Amidino compounds, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |