Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.76 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.76 |
| ▸ | ACHE | P22303 | 4/20 | 0.45 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | APP | P05067 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | SNCA | P37840 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL3182319 | 1.00 | LTB4R (0.76) | LTB4RLTB4R2ACHEPLA2G4BMAPT | |
| SCHEMBL7711975 | 0.95 | LTB4R (0.72) | LTB4RLTB4R2ACHEPLA2G4BMAPT | |
| Hydrochloric Acid SCHEMBL8994890 | 0.94 | LTB4R (0.71) | LTB4RLTB4R2ACHEPLA2G4BMAPT | |
| SCHEMBL9702013 | 0.93 | LTB4R (0.68) | LTB4RLTB4R2PLA2G4BMAPTKDM4E | |
| SCHEMBL8994985 | 0.93 | LTB4R (0.68) | LTB4RLTB4R2PLA2G4BMAPTKDM4E | |
| Hydrochloric Acid SCHEMBL8995021 | 0.91 | LTB4R (0.68) | LTB4RLTB4R2PLA2G4BMAPTPRSS1 | |
| SCHEMBL8994967 | 0.89 | LTB4R (0.63) | LTB4RLTB4R2PLA2G4BMAPTKDM4E | |
| SCHEMBL9699613 | 0.86 | LTB4R (0.59) | LTB4RLTB4R2ACHEPLA2G4BMAPT | |
| Moxilubant SCHEMBL1231167 | 0.86 | LTB4R (1.00) | LTB4RLTB4R2ACHEPLA2G4BMAPT | |
| Moxilubant SCHEMBL29366878 | 0.86 | LTB4R (1.00) | LTB4RLTB4R2ACHEPLA2G4BMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2001034199-A2 | ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER | ELI LILLY AND COMPANY (US) | 2001-05-17 | — | — | WO | claimed |
| WO-2001034199-A2 | ONCOLYTIC COMBINATIONS FOR THE TREATMENT OF CANCER | ELI LILLY AND COMPANY (US) | 2001-05-17 | — | — | WO | disclosed |