Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.57 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.40 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9701994 | 0.90 | LTB4R (0.47) | LTB4RLTB4R2KDM4EALDH1A1MEN1 | |
| SCHEMBL9117727 | 0.82 | LTB4R (0.52) | LTB4RLTB4R2ALDH1A1PLA2G4B | |
| SCHEMBL7711975 | 0.82 | LTB4R (0.72) | LTB4RLTB4R2KDM4EALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL8994941 | 0.82 | LTB4R (0.51) | LTB4RLTB4R2ALDH1A1PLA2G4B | |
| Hydrochloric Acid SCHEMBL8994890 | 0.81 | LTB4R (0.71) | LTB4RLTB4R2KDM4EALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL8995021 | 0.81 | LTB4R (0.68) | LTB4RLTB4R2MAPTPLA2G4B | |
| Hydrochloric Acid SCHEMBL8994966 | 0.81 | LTB4R (0.49) | LTB4RLTB4R2ALDH1A1MEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8995013 | 0.80 | LTB4R (0.56) | LTB4RLTB4R2KDM4EALDH1A1MAOB | |
| SCHEMBL9702013 | 0.80 | LTB4R (0.68) | LTB4RLTB4R2KDM4EALDH1A1MEN1 | |
| SCHEMBL8994985 | 0.80 | LTB4R (0.68) | LTB4RLTB4R2KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |