Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.45 |
| ▸ | THRA | P10827 | 2/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.42 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.40 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | LSS | P48449 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8995071 | 0.86 | LTB4R (0.56) | LTB4RTHRATHRBLTB4R2LSS | |
| Hydrochloric Acid SCHEMBL8994980 | 0.86 | LTB4R (0.56) | LTB4RTHRATHRBLTB4R2LSS | |
| SCHEMBL8994948 | 0.81 | LTB4R (0.59) | LTB4RTHRATHRBLTB4R2LSS | |
| SCHEMBL8994910 | 0.79 | LTB4R (0.55) | LTB4RTHRATHRBLTB4R2TSHR | |
| Hydrochloric Acid SCHEMBL8590502 | 0.78 | LTB4R (0.48) | LTB4RTHRATHRBLTB4R2TSHR | |
| SCHEMBL8591184 | 0.78 | LTB4R (0.48) | LTB4RLTB4R2TSHR | |
| Hydrochloric Acid SCHEMBL8589791 | 0.77 | LTB4R (0.47) | LTB4RTHRATHRBLTB4R2CYP1A2 | |
| SCHEMBL8994878 | 0.77 | LTB4R (0.50) | LTB4RTHRATHRBLTB4R2TSHR | |
| Hydrochloric Acid SCHEMBL8593811 | 0.76 | LTB4R (0.48) | LTB4RTHRATHRBLTB4R2MAPT | |
| Hydrochloric Acid SCHEMBL8593266 | 0.76 | LTB4R (0.46) | LTB4RTHRATHRBLTB4R2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-A2 | Amidino compounds, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |