Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 2/20 | 0.56 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.52 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | THRA | P10827 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994912 | 0.89 | LTB4R (0.59) | LTB4RLTB4R2PLA2G4BTHRATHRB | |
| Hydrochloric Acid SCHEMBL8995026 | 0.87 | LTB4R (0.71) | LTB4RLTB4R2PLA2G4BTHRATHRB | |
| SCHEMBL8994887 | 0.86 | LTB4R (0.76) | LTB4RLTB4R2PLA2G4BTHRATHRB | |
| SCHEMBL8747942 | 0.84 | LTB4R (0.53) | LTB4RLTB4R2PLA2G4BTHRATHRB | |
| SCHEMBL8994906 | 0.83 | LTB4R (0.53) | LTB4RLTB4R2PLA2G4BPRSS1MAPT | |
| SCHEMBL8995065 | 0.82 | SMPD1 (0.57) | LTB4RPLA2G4BPRSS1SMPD1 | |
| SCHEMBL8994986 | 0.82 | HTT (0.53) | LTB4RLTB4R2PLA2G4BMAPTBCHE | |
| SCHEMBL8994910 | 0.82 | LTB4R (0.55) | LTB4RLTB4R2PLA2G4BTHRATHRB | |
| SCHEMBL8995032 | 0.82 | SMPD1 (0.51) | LTB4RLTB4R2PLA2G4BPRSS1MAPT | |
| SCHEMBL8995067 | 0.80 | LTB4R (0.57) | LTB4RLTB4R2PLA2G4BMAPTBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |
| EP-0518819-A2 | Amidino compounds, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |