Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 5/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 3/20 | 0.50 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.49 |
| ▸ | CRHBP | P24387 | 1/20 | 0.48 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8995032 | 0.92 | SMPD1 (0.51) | SMPD1TP53PLA2G4BSLC6A5LTB4R | |
| SCHEMBL8994906 | 0.90 | LTB4R (0.53) | SMPD1PLA2G4BLTB4RMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL8994963 | 0.87 | LTB4R (0.63) | SMPD1TP53PLA2G4BCNR2LTB4R | |
| SCHEMBL8994951 | 0.87 | DRD2 (0.56) | PLA2G4BROCK2 | |
| SCHEMBL8994912 | 0.82 | LTB4R (0.59) | PLA2G4BLTB4RPOLBPRSS1 | |
| SCHEMBL8995031 | 0.82 | LTB4R (0.56) | SMPD1PLA2G4BLTB4RPRSS1 | |
| SCHEMBL8994887 | 0.80 | LTB4R (0.76) | PLA2G4BLTB4RPOLBPRSS1 | |
| Hydrochloric Acid SCHEMBL8994975 | 0.80 | SMPD1 (0.57) | SMPD1TP53PLA2G4BSLC6A5CNR2 | |
| SCHEMBL8995063 | 0.79 | HPGD (0.65) | TP53PLA2G4BLTB4RMEN1KMT2A | |
| SCHEMBL8994972 | 0.78 | HPGD (0.64) | TP53PLA2G4BLTB4RMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |
| EP-0518819-B1 | Amidino compounds, their manufacture and use as medicament | CIBA GEIGY AG (CH) | 1995-08-02 | — | — | EP | disclosed |
| EP-0518819-A2 | Amidino compounds, their manufacture and use as medicament | CIBA-GEIGY AG (CH) | 1992-12-16 | — | — | EP | disclosed |