Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R | Q15722 | 3/20 | 0.71 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.65 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | REN | P00797 | 2/20 | 0.42 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8995057 | 0.92 | LTB4R (0.70) | LTB4RLTB4R2PRSS1PLA2G4BSMPD1 | |
| SCHEMBL8994880 | 0.91 | LTB4R (0.74) | LTB4RLTB4R2PRSS1PLA2G4BSMPD1 | |
| SCHEMBL8994930 | 0.90 | LTB4R (0.75) | LTB4RLTB4R2PRSS1PLA2G4BSMPD1 | |
| SCHEMBL8994891 | 0.90 | LTB4R (0.75) | LTB4RLTB4R2PRSS1PLA2G4BMAPT | |
| SCHEMBL8995017 | 0.89 | LTB4R (0.66) | LTB4RLTB4R2PRSS1PLA2G4BMAPT | |
| SCHEMBL8994895 | 0.88 | LTB4R (0.72) | LTB4RLTB4R2PRSS1PLA2G4BSMPD1 | |
| SCHEMBL8994902 | 0.88 | LTB4R (0.72) | LTB4RLTB4R2PRSS1PLA2G4BSMPD1 | |
| SCHEMBL8747956 | 0.88 | LTB4R (0.78) | LTB4RLTB4R2PRSS1PLA2G4BSMPD1 | |
| SCHEMBL8748241 | 0.88 | LTB4R (0.78) | LTB4RLTB4R2PRSS1PLA2G4BSMPD1 | |
| SCHEMBL8748238 | 0.88 | LTB4R (0.78) | LTB4RLTB4R2PRSS1PLA2G4BSMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5488160-A | LEUKOTRIENE B4 RECEPTOR ANTAGONIST AS ANTIINFLAMMATORY AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-01-30 | — | — | US | disclosed |
| US-5451700-A | Leukotriene inhibitors | CIBA-GEIGY CORPORATION (US) | 1995-09-19 | — | — | US | disclosed |