Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 3/20 | 0.72 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.72 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menthol SCHEMBL18787982 | 0.91 | TRPM8 (0.60) | TRPM8TRPA1LMNAEPHX1ALDH1A1 | |
| Menthol SCHEMBL3378958 | 0.88 | TRPM8 (0.75) | TRPM8TRPA1LMNAEPHX1ALDH1A1 | |
| Menthol SCHEMBL27488961 | 0.87 | TRPM8 (0.88) | TRPM8TRPA1LMNAEPHX1ALDH1A1 | |
| Levomenthol SCHEMBL22227514 | 0.85 | TRPM8 (0.84) | TRPM8TRPA1LMNAEPHX1ALDH1A1 | |
| Menthol SCHEMBL28157641 | 0.85 | TRPM8 (0.84) | TRPM8TRPA1LMNAEPHX1ALDH1A1 | |
| Menthol SCHEMBL4086460 | 0.85 | TRPM8 (0.84) | TRPM8TRPA1LMNAEPHX1ALDH1A1 | |
| (+)-Menthol SCHEMBL13059620 | 0.85 | TRPM8 (1.00) | TRPM8TRPA1LMNAEPHX1ALDH1A1 | |
| Racementhol SCHEMBL521946 | 0.85 | TRPM8 (1.00) | TRPM8TRPA1LMNAEPHX1ALDH1A1 | |
| (+)-Menthol SCHEMBL10072505 | 0.85 | TRPM8 (1.00) | TRPM8TRPA1LMNAEPHX1ALDH1A1 | |
| Menthol SCHEMBL20771511 | 0.85 | TRPM8 (1.00) | TRPM8TRPA1LMNAEPHX1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0552234-B1 | A COMBINATION FOR IMPROVED DELIVERY OF TOBACCO MODIFYING AGENTS | EASTMAN CHEM CO (US) | 1996-08-21 | — | — | EP | disclosed |
| US-5356704-A | Enhancing the flavor of tobacco smoke; using fibers capable of transporting water on their surfaces | EASTMAN CHEMICAL COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| US-5275859-A | Fiber having at least one continuous groove capable of spontaneously transporting n-decane on its surface | EASTMAN KODAK COMPANY (US) | 1994-01-04 | — | — | US | disclosed |
| EP-0552234-A1 | A COMBINATION FOR IMPROVED DELIVERY OF TOBACCO MODIFYING AGENTS. | EASTMAN KODAK CO (US) | 1993-07-28 | — | — | EP | disclosed |
| WO-1992005713-A1 | A COMBINATION FOR IMPROVED DELIVERY OF TOBACCO MODIFYING AGENTS | EASTMAN KODAK COMPANY (US) | 1992-04-16 | — | — | WO | disclosed |