Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Racementhol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 5/20 | 1.00 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 1.00 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (+)-Menthol SCHEMBL10072505 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL15449169 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Isomenthol SCHEMBL677675 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL9968934 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL1709231 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+) Neomenthol SCHEMBL260049 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL12646785 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL13059620 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| Menthol SCHEMBL20771511 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 | |
| (+)-Menthol SCHEMBL2454317 | 1.00 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 715 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122079744-A | Method for resolution of D, L-menthol enantiomer | — | 2026-05-26 | — | — | CN | claimed |
| CN-122060258-A | Long-acting antibacterial mildew-proof resin material for edge banding and preparation method thereof | 湖北登泰新材科技有限公司 | 2026-05-19 | — | — | CN | claimed |
| US-12630855-B2 | Polypeptide having esterification activity for L-menthol and/or hydrolyzing activity for L-menthol ester | AMANO ENZYME INC. (JP) | 2026-05-19 | — | — | US | claimed |
| EP-3720563-B9 | ORAL CARE COMPOSITIONS | KENVUE BRANDS LLC (US) | 2026-05-06 | — | — | EP | claimed |
| EP-3720563-B1 | ORAL CARE COMPOSITIONS | KENVUE BRANDS LLC (US) | 2026-01-07 | — | — | EP | claimed |
| EP-4663203-A1 | COMBINATION OF SGLT2 INHIBITOR AND MENTHOL AND USE THEREOF IN TREATMENT OF HEART DISEASE | East China University of Science and Technology (CN) | 2025-12-17 | — | — | EP | claimed |
| US-20250360091-A1 | COMBINATION OF SGLT2 INHIBITOR AND MENTHOL AND USE THEREOF IN TREATMENT OF HEART DISEASE | UNIV EAST CHINA SCIENCE & TECH (CN) | 2025-11-27 | — | — | US | claimed |
| EP-3313372-B2 | PACKAGED SILICONE LUBRICATED CONDOM THAT PROVIDES SENSATION | LIFESTYLES HEALTHCARE PTE LTD (SG) | 2025-11-26 | — | — | EP | claimed |
| US-20250352444-A1 | Antimicrobial mixtures | SYMRISE AG (DE) | 2025-11-20 | — | — | US | claimed |
| US-20250325463-A1 | COMPOSITIONS (III) | SYMRISE AG (DE) | 2025-10-23 | — | — | US | claimed |
| CN-109704943-B | Method for preparing optically pure L-menthone and catalyst used in method | 万华化学集团股份有限公司 | 2022-07-12 | — | — | CN | claimed |
| CN-113292532-B | Polysubstituted naphthoquinone derivative and preparation method and application thereof | 中山大学 | 2022-06-28 | — | — | CN | claimed |
| WO-2022122134-A1 | COMPOSITIONS WITH (BIO)-ALKANEDIOLS AND COOLING AGENTS | SYMRISE AG (DE) | 2022-06-16 | — | — | WO | claimed |
| WO-2022122903-A1 | COMPOSITIONS COMPRISING (BIO)-ALKANEDIOLS AND COOLING AGENTS | SYMRISE AG (DE) | 2022-06-16 | — | — | WO | claimed |
| CN-110841613-B | Chiral separation multifunctional cellulose-based material and preparation method thereof | 合肥工业大学 | 2022-05-17 | — | — | CN | claimed |
| CN-114487169-A | Chiral amino acid detection method | 宁波大学 | 2022-05-13 | — | — | CN | claimed |
| CN-112250556-B | Preparation method of menthone | 万华化学集团股份有限公司 | 2022-04-22 | — | — | CN | claimed |
| CN-111617646-B | Preparation method of chiral conjugated microporous polymer/silicon dioxide composite membrane | 齐齐哈尔大学 | 2022-03-04 | — | — | CN | claimed |
| US-20180280294-A1 | THERAPEUTIC PUTTY HAVING ANALGESICS AND/OR COUNTERIRRITANTS | GOLDBERG, ELLIOTT | 2018-10-04 | — | — | US | claimed |
| EP-1218063-B1 | PHARMACEUTICAL COMPOSITION CONTAINING TRICHLOROACETIC ACID, 2-OH BENZOIC ACID AND MENTHOL FOR TOPICAL APPLICATION AND PROCESS FOR THE PREPARATION THEREOF | STRUMILLO MARIA (IT) | 2004-04-14 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250352444-A1 | Antimicrobial mixtures | LRBA, MGLL, TAS2R50 | TRPM8 205/4885TRPA1 71/4885EPHX1 3703/4885 |
| US-12630855-B2 | Polypeptide having esterification activity for L-menthol and/or hydrolyzing activity for L-menthol ester | MLEC, METTL16, METTL14 | TRPM8 326/4885TRPA1 2828/4885EPHX1 1607/4885 |
| US-20250325463-A1 | COMPOSITIONS (III) | NISCH, TAS1R3, TAS2R3 | TRPM8 171/4885TRPA1 4/4885EPHX1 3052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.