Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Menthol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 known ✓ | Q7Z2W7 | 3/20 | 0.84 |
| ▸ | TRPA1 known ✓ | O75762 | 2/20 | 0.84 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Menthol SCHEMBL28157641 | 1.00 | TRPM8 (0.84) | TRPM8TRPA1EPHX1ALDH1A1OPRM1 | |
| Levomenthol SCHEMBL22227514 | 1.00 | TRPM8 (0.84) | TRPM8TRPA1EPHX1ALDH1A1OPRM1 | |
| Menthol SCHEMBL27488961 | 0.94 | TRPM8 (0.88) | TRPM8TRPA1EPHX1ALDH1A1OPRM1 | |
| Menthol SCHEMBL3648445 | 0.92 | TRPM8 (0.84) | TRPM8TRPA1EPHX1ALDH1A1OPRM1 | |
| (+)-Menthol SCHEMBL10072505 | 0.92 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1OPRM1 | |
| Isomenthol SCHEMBL677675 | 0.92 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1OPRM1 | |
| (+)-Menthol SCHEMBL15449169 | 0.92 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1OPRM1 | |
| Menthol SCHEMBL20771511 | 0.92 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1OPRM1 | |
| (+)-Menthol SCHEMBL12646785 | 0.92 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1OPRM1 | |
| (+)-Menthol SCHEMBL1709231 | 0.92 | TRPM8 (1.00) | TRPM8TRPA1EPHX1ALDH1A1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 74 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115209731-B | Cleaning composition | 联合利华知识产权控股有限公司 | 2024-07-02 | — | — | CN | claimed |
| CN-116763895-A | Plant extracted volatile oil with fatigue relieving and pain relieving effects and preparation and application thereof | 天津益生元特医食品有限责任公司 | 2023-09-19 | — | — | CN | claimed |
| CN-116672427-A | Natural plant volatile oil for relieving dizziness and headache as well as preparation method and application thereof | 北京凯晨医药信息技术有限责任公司 | 2023-09-01 | — | — | CN | claimed |
| CN-106138156-B | Traditional Chinese medicine preparation for clearing heat and relieving sore throat and preparation method thereof | 阙锋 | 2020-07-10 | — | — | CN | claimed |
| EP-3672932-A1 | METHOD FOR PRODUCING TERPENE ALDEHYDES AND TERPENE KETONES | Symrise AG (DE) | 2020-07-01 | — | — | EP | claimed |
| CN-108653456-A | A kind of swelling and pain relieving patch and preparation method thereof | 数源汇通（北京）医药科技有限公司 | 2018-10-16 | — | — | CN | claimed |
| CN-108064990-A | A kind of solid tea containing Ramulus et Folium Mussaendae Pubescentis extract | 罗世耀 | 2018-05-25 | — | — | CN | claimed |
| CN-104547512-B | A pharmaceutical composition for treating pharyngeal diseases, and its preparation method | 青岛市市立医院 | 2018-01-12 | — | — | CN | claimed |
| US-20160009616-A1 | Method for Producing a Water Soluble Menthol Compounds having Antibacterial, Anti-Inflammatory, and Bacteriostatic Effects | HSIN WEN HSIANG WAYNE (US) | 2016-01-14 | — | — | US | claimed |
| EP-2344547-B1 | POLYSACCHARIDES CONTAINING CARBOXYL FUNCTIONAL GROUPS SUBSTITUTED BY A HYDROPHOBIC ALCOHOL DERIVATIVE | ADOCIA (FR) | 2014-12-03 | — | — | EP | claimed |
| EP-0101578-B1 | DISPENSING FRAGRANCES | Union Camp Corporation (US) | 1986-12-30 | — | — | EP | claimed |
| JP-10066639-A | — | — | None | — | — | JP | disclosed |
| CN-120708746-A | Preparation of menthol-containing tobacco bud inhibitor and compound decrement synergy method thereof | 中国农业科学院烟草研究所(中国烟草总公司青州烟草研究所) | 2025-09-26 | — | — | CN | disclosed |
| EP-3777581-B1 | ELECTRONIC CIGARETTE FILLER AND ELECTRONIC CIGARETTE CARTRIDGE | FUTURE TECHNOLOGY CO LTD (JP) | 2024-06-05 | — | — | EP | disclosed |
| CN-117357661-A | Composition for preventing and treating asthenopia and xerophthalmia, eye mask and preparation method thereof | 河南康林实业有限公司 | 2024-01-09 | — | — | CN | disclosed |
| US-4966169-A | SPRAYING TOBACCO WITH ALCOHOL | C. A. BLOCKERS, INC. (US) | 1990-10-30 | — | — | US | disclosed |
| US-4963591-A | CELLULOSE ETHER IN LOWER ALIPHATIC ALCOHOL SOLVENT | CARTER-WALLACE INC. (US) | 1990-10-16 | — | — | US | disclosed |
| WO-1989006911-A1 | PROCESS FOR MANUFACTURING CIGARETTES EMPLOYING PRESELECTED ALCOHOLS | C.A. BLOCKERS, INC. (US) | 1989-08-10 | — | — | WO | disclosed |
| WO-1989006912-A1 | PROCESS FOR MANUFACTURING CIGARETTES EMPLOYING PRESELECTED ALCOHOLS | BLOCKERS C A INC (US) | 1989-08-10 | — | — | WO | disclosed |
| US-3962341-A | Production of piperitenone | BASF AKTIENGESELLSCHAFT (DT) | 1976-06-08 | — | — | US | disclosed |