Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.52 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.51 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | ATP4A | P20648 | 2/20 | 0.48 |
| ▸ | ATP4B | P51164 | 2/20 | 0.48 |
| ▸ | DHFR | P00374 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4277540 | 0.83 | HSP90AA1 (0.71) | MAP4K4HRH4ADORA2AADORA1ADORA2B | |
| SCHEMBL7383081 | 0.83 | ATP4A (0.47) | ATP4AATP4B | |
| SCHEMBL18931741 | 0.81 | KDM4E (0.58) | HRH4ADORA2AADORA1KDM4EHSP90AA1 | |
| SCHEMBL3451102 | 0.80 | ADORA2A (0.73) | HRH4ADORA2AADORA1KDM4EHSP90AA1 | |
| SCHEMBL5747382 | 0.80 | HSP90AA1 (0.58) | MAP4K4HRH4ADORA2AADORA1ADORA2B | |
| SCHEMBL19762220 | 0.77 | MEN1 (0.50) | ADORA2AADORA1KDM4E | |
| SCHEMBL2324638 | 0.73 | ADORA2A (0.53) | MAP4K4HRH4ADORA2AADORA1ADORA2B | |
| SCHEMBL14413006 | 0.73 | HSP90AA1 (0.67) | MAP4K4HRH4ADORA2AADORA1ADORA2B | |
| SCHEMBL15757436 | 0.73 | HRH4 (0.57) | MAP4K4HRH4ADORA2AADORA1ADORA2B | |
| SCHEMBL9566496 | 0.73 | RAB9A (0.61) | MAP4K4HRH4ADORA2AADORA1ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5554617-A | Method for treating cancer with 6-aryl pyrimidine compounds | THE UPJOHN COMPANY (US) | 1996-09-10 | — | — | US | disclosed |
| US-5434157-A | Active against herpes, hepatitis, papovavirus | THE UPJOHN COMPANY (US) | 1995-07-18 | — | — | US | disclosed |
| US-5002951-A | 2-amino-5-halo-4-pyrimidinol for bactericides and antiprotozoa agent | THE UPJOHN COMPANY (US) | 1991-03-26 | — | — | US | disclosed |
| US-4665077-A | IMMUNOREGULATORY AGENTS | THE UPJOHN COMPANY (US) | 1987-05-12 | — | — | US | disclosed |
| US-4619933-A | 6-aryl pyrimidines for treating aplastic anemia | THE UPJOHN COMPANY (US) | 1986-10-28 | — | — | US | disclosed |
| US-4543248-A | Method for immunoregulation with 6-aryl pyrimidine compounds | THE UPJOHN COMPANY (US) | 1985-09-24 | — | — | US | disclosed |
| US-4507302-A | Method for treating arthritis with 6-aryl pyrimidine compounds | THE UPJOHN COMPANY (US) | 1985-03-26 | — | — | US | disclosed |