SCHEMBL899595

SCHEMBL899595

C=Cc1ccc([Si](C)(Cl)Cl)cc1

nearest known ligand 0.52

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.52
TSHR P16473 1/20 0.40
HDAC8 Q9BY41 3/20 0.39
TDP1 Q9NUW8 2/20 0.35
TP53 P04637 2/20 0.32
CHRNB2 P17787 1/20 0.32
CHRNB4 P30926 1/20 0.32
CHRNA3 P32297 1/20 0.32
CHRNA7 P36544 1/20 0.32
CHRNA4 P43681 1/20 0.32
TRPA1 O75762 1/20 0.31
MEN1 O00255 1/20 0.30
MAPT P10636 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4601562 0.86 ALDH1A1 (0.52) ALDH1A1TSHRHDAC8TDP1TP53
SCHEMBL9636010 0.80 ALDH1A1 (0.58) ALDH1A1TSHRHDAC8TDP1TP53
SCHEMBL2167411 0.80 ALDH1A1 (0.58) ALDH1A1TSHRHDAC8TDP1TP53
SCHEMBL141101 0.80 ALDH1A1 (0.58) ALDH1A1TSHRHDAC8TDP1TP53
SCHEMBL7649599 0.80 ALDH1A1 (0.58) ALDH1A1TSHRHDAC8TDP1TP53
SCHEMBL703791 0.79 ALDH1A1 (0.36) ALDH1A1
SCHEMBL15473032 0.76 ALDH1A1 (0.52) ALDH1A1TSHRHDAC8TDP1TP53
SCHEMBL8758099 0.76 ALDH1A1 (0.52) ALDH1A1TSHRHDAC8TDP1TP53
SCHEMBL30991325 0.76 ALDH1A1 (0.52) ALDH1A1TSHRHDAC8TDP1TP53
SCHEMBL9488658 0.76 ALDH1A1 (0.52) ALDH1A1TSHRHDAC8TDP1TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20060142500-A1 Multi-branched styrene-conjugated diene block copolymer and its preparation method KOREA KUMHO PETROCHEMICAL CO., LTD. (KR) 2006-06-29 US claimed
US-20050182191-A1 Multi-branched styrene-conjugated diene block copolymer and its preparation method KOREA KUMHO PETROCHEMICAL CO., LTD. (KR) 2005-08-18 US claimed
US-6756448-B2 SYNDIOTACTIC; LIVING BUTADIENE OR ISOPRENE POLYMER BY ANIONIC POLYMERIZATION WITH ALKYLLITHIUM CATALYST AND THEN REACTION WITH A P-SILYLSTYRENE TERMINAL MODIFIER; FURTHER COPOLYMERIZATION WITH STYRENE KOREA KUMHO PETROCHEMICAL CO., LTD. (KR) 2004-06-29 US claimed
US-20040059075-A1 Styrene copolymer KOREA KUMHO PETROCHEMICAL CO., LTD. (KR) 2004-03-25 US claimed
CN-112300495-A Silicon dioxide and propane-butadiene copolymer compound and preparation method thereof 中国石油天然气股份有限公司 2021-02-02 CN disclosed
US-9708434-B2 Multigraft copolymers as superelastomers UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2017-07-18 US disclosed
US-9708434-B2 Multigraft copolymers as superelastomers UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2017-07-18 US disclosed
EP-2622015-B1 MULTIGRAFT COPOLYMERS AS SUPERELASTOMERS UNIV TENNESSEE RES FOUNDATION (US) 2015-12-16 EP disclosed
US-20140161858-A1 Multigraft Copolymers as Superelastomers UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2014-06-12 US disclosed
US-20140161858-A1 Multigraft Copolymers as Superelastomers UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) 2014-06-12 US disclosed
EP-2622015-A1 MULTIGRAFT COPOLYMERS AS SUPERELASTOMERS University of Tennessee Research Foundation (US) 2013-08-07 EP disclosed
US-8168724-B2 Synthesis and use of well-defined, highly-branched saturated hydrocarbon polymers EXXONMOBIL RESEARCH AND ENGINEERING COMPANY (US) 2012-05-01 US disclosed
EP-0442804-A1 Multi-block functionalized macromonomers and their method of manufacture ELF ATOCHEM S.A. (FR) 1991-08-21 EP disclosed
EP-0419314-A1 Process for preparing functionalised (meth)acrylic macromonomers and macromonomers so prepared ELF ATOCHEM S.A. (FR) 1991-03-27 EP disclosed
WO-1991003502-A1 METHOD FOR PRODUCING FUNCTIONALIZED (METH)ACRYLIC MACROMONOMERS AND MACROMONOMERS THUS OBTAINED ATOCHEM (FR) 1991-03-21 WO disclosed
US-4996266-A Branched elastomeric and block copolymers MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1991-02-26 US disclosed
US-4906691-A Adhesive compositions made with condensed phase polymers and sheet materials coated therewith MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1990-03-06 US disclosed
EP-0349920-A2 Polyorganosiloxane Chisso Corporation (JP) 1990-01-10 EP disclosed
US-4857618-A ELASTOMERIC, ANIONIC COPOLYMERS; ORGANOMETALLIC CONDENSING AGENT; PRESSURE SENSITIVE ADHESIVES MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1989-08-15 US disclosed
US-4857615-A Method of making condensed phase polymers MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1989-08-15 US disclosed