Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | GPR174 | Q9BXC1 | 3/20 | 0.42 |
| ▸ | HRH2 | P25021 | 3/20 | 0.40 |
| ▸ | HRH1 | P35367 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL899935 | 0.81 | MAPT (0.58) | MAPTKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL28615895 | 0.80 | SMN1; SMN2 (0.48) | MAPTKMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL29742046 | 0.80 | MAPT (0.58) | MAPTKMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL27927938 | 0.79 | MAPT (0.42) | MAPTKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL27694790 | 0.77 | MAPT (0.49) | MAPTKMT2ALMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL27464372 | 0.76 | MAPT (0.79) | MAPTKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL20524642 | 0.76 | MAPT (0.44) | MAPTKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL25263883 | 0.74 | SIRT6 (0.60) | MAPTKMT2AMEN1LMNAALDH1A1 | |
| SCHEMBL29742079 | 0.74 | MAPT (0.55) | MAPTKMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL15569212 | 0.72 | MAPT (0.50) | MAPTLMNAALDH1A1SMN1; SMN2HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2621920-A1 | NOVEL PIPERAZINE ANALOGS WITH SUBSTITUTED HETEROARYL GROUPS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS | Bristol-Myers Squibb Company (US) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012044531-A1 | NOVEL PIPERAZINE ANALOGS WITH SUBSTITUTED HETEROARYL GROUPS AS BROAD-SPECTRUM INFLUENZA ANTIVIRALS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-04-05 | — | — | WO | disclosed |