SCHEMBL8996444

SCHEMBL8996444

CC(=O)Oc1c(C(=O)O)cc(O)c2c1C(=O)c1ccccc1C2=O

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TTR P02766 3/20 0.47
MAPT P10636 7/20 0.46
KDM4E B2RXH2 7/20 0.46
ALDH1A1 P00352 6/20 0.46
MAPK1 P28482 5/20 0.46
HSD17B10 Q99714 5/20 0.46
MEN1 O00255 4/20 0.46
KMT2A Q03164 4/20 0.46
HPGD P15428 3/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
MAOA P21397 2/20 0.46
TDP1 Q9NUW8 2/20 0.46
MMP14 P50281 2/20 0.46
RECQL P46063 2/20 0.46
CYP1A1 P04798 1/20 0.46
CYP3A4 P08684 1/20 0.46
HSPD1 P10809 1/20 0.46
ALOX15 P16050 1/20 0.46
ALOX12 P18054 1/20 0.46
ACHE P22303 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2148493 0.90 ALDH1A1 (0.51) TTRMAPTKDM4EALDH1A1MAPK1
SCHEMBL8996376 0.86 TTR (0.51) TTRMAPTKDM4EALDH1A1MAPK1
SCHEMBL11233502 0.82 TTR (0.55) TTRMAPTKDM4EALDH1A1MAPK1
SCHEMBL27916746 0.80 MAPT (0.57) TTRMAPTKDM4EALDH1A1MAPK1
SCHEMBL12581680 0.79 TTR (0.44) TTRMAPTKDM4EALDH1A1MAPK1
SCHEMBL23522461 0.78 TTR (0.56) TTRMAPTKDM4EALDH1A1MAPK1
SCHEMBL8996447 0.77 MAPT (0.66) TTRMAPTKDM4EALDH1A1MAPK1
SCHEMBL8996409 0.76 KDM4E (0.64) TTRMAPTKDM4EALDH1A1MAPK1
SCHEMBL22323640 0.76 MAPT (0.44) TTRMAPTKDM4EALDH1A1HSD17B10
SCHEMBL10602479 0.75 MEN1 (0.58) TTRMAPTKDM4EALDH1A1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0570091-A1 Anthraquinone derivatives, process for their preparation and their use as medicaments LILLY INDUSTRIES LIMITED (GB) 1993-11-18 EP claimed
US-5480873-A ARTHRITIS LILLY INDUSTRIES LIMITED (GB) 1996-01-02 US disclosed
EP-0570091-A1 Anthraquinone derivatives, process for their preparation and their use as medicaments LILLY INDUSTRIES LIMITED (GB) 1993-11-18 EP disclosed