Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.51 |
| ▸ | TTR | P02766 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.51 |
| ▸ | RECQL | P46063 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.51 |
| ▸ | CASP7 | P55210 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8996444 | 0.90 | TTR (0.47) | ALDH1A1MAPTKDM4ETTRHPGD | |
| SCHEMBL8996409 | 0.80 | KDM4E (0.64) | ALDH1A1MAPTKDM4ETTRHPGD | |
| SCHEMBL8996324 | 0.80 | FTO (0.68) | ALDH1A1MAPTKDM4ETTRHPGD | |
| SCHEMBL8963432 | 0.78 | ALDH1A1 (0.57) | ALDH1A1MAPTKDM4ETTRHPGD | |
| SCHEMBL8996376 | 0.76 | TTR (0.51) | ALDH1A1MAPTKDM4ETTRHPGD | |
| SCHEMBL22394347 | 0.74 | PIM1 (0.63) | ALDH1A1MAPTKDM4ETTRHPGD | |
| SCHEMBL27916746 | 0.73 | MAPT (0.57) | ALDH1A1MAPTKDM4ETTRHPGD | |
| SCHEMBL9538649 | 0.73 | MEN1 (0.64) | ALDH1A1MAPTKDM4ETTRHPGD | |
| SCHEMBL11526641 | 0.73 | PIM1 (0.69) | ALDH1A1MAPTKDM4ETTRHPGD | |
| SCHEMBL16459296 | 0.72 | MAPT (0.45) | ALDH1A1MAPTKDM4ETTRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116919957-A | Methods and pharmaceutical compositions for preventing or treating immunoinflammatory skin disorders | 安成生物科技股份有限公司 | 2023-10-24 | — | — | CN | disclosed |
| EP-3570835-B1 | DIACEREIN FOR PREVENTING OR TREATING IMMUNOINFLAMMATORY DERMAL DISORDERS | TWI BIOTECHNOLOGY INC (TW) | 2023-08-09 | — | — | EP | disclosed |
| CN-110191710-B | Method and pharmaceutical composition for preventing or treating immunoinflammatory skin disorders | 安成生物科技股份有限公司 | 2023-04-18 | — | — | CN | disclosed |
| EP-4147694-A1 | DIACEREIN OR ITS ANALOGS FOR INHIBITING EXPRESSION OF ASC, NLRP3, AND/OR FORMATION OF NLRP3 INFLAMMASOME COMPLEX | TWI Biotechnology, Inc. (TW) | 2023-03-15 | — | — | EP | disclosed |
| CN-108349867-B | Diacerein or analogues thereof for inhibiting the expression of ASC, the expression of NLRP3 and/or the formation of NLRP3 inflammatory complex | 安成生物科技股份有限公司 | 2021-03-09 | — | — | CN | disclosed |
| US-10675260-B2 | Methods and pharmaceutical compositions for preventing or treating immunoinflammatory dermal disorders | TWI BIOTECHNOLOGY, INC. (TW) | 2020-06-09 | — | — | US | disclosed |
| US-20190105296-A1 | DIACEREIN OR RHEIN TOPICAL FORMULATIONS AND USES THEREOF | TWI BIOTECHNOLOGY, INC. (TW) | 2019-04-11 | — | — | US | disclosed |
| EP-3452169-A1 | METHODS AND FORMULATIONS FOR TREATMENT AND/OR PREVENTION OF BLOOD-ASSOCIATED DISORDERS | TWI Biotechnology, Inc. (TW) | 2019-03-13 | — | — | EP | disclosed |
| US-10195170-B2 | Methods for inhibiting expression of ASC, expression of NLRP3, and/or formation of NLRP3 inflammasome complex using diacerein or its analogs | TWI BIOTECHNOLOGY, INC. (TW) | 2019-02-05 | — | — | US | disclosed |
| US-10154984-B2 | Diacerein or Rhein topical formulations and uses thereof | TWI BIOTECHNOLOGY, INC. (TW) | 2018-12-18 | — | — | US | disclosed |
| US-20110166225-A1 | ORAL LIQUID COMPOSITIONS OF RHEIN OR DIACEREIN | VERMA HIMANSHU | 2011-07-07 | — | — | US | disclosed |
| US-20100303902-A1 | SELF-EMULSIFYING PHARMACEUTICAL COMPOSITIONS OF RHEIN OR DIACEREIN | NAKHAT PREMCHAND | 2010-12-02 | — | — | US | disclosed |
| US-20100285114-A1 | PHARMACEUTICAL COMPOSITIONS OF RHEIN OR DIACEREIN | DABRE RAHUL | 2010-11-11 | — | — | US | disclosed |
| EP-2224914-A2 | RHEIN OR DIACEREIN COMPOSITIONS | Wockhardt Research Centre (IN) | 2010-09-08 | — | — | EP | disclosed |
| EP-2207531-A1 | SELF-EMULSIFYING PHARMACEUTICAL COMPOSITIONS OF RHEIN OR DIACEREIN | Wockhardt Research Centre (IN) | 2010-07-21 | — | — | EP | disclosed |
| EP-2207532-A2 | PHARMACEUTICAL COMPOSITIONS OF RHEIN OR DIACEREIN | Wockhardt Research Centre (IN) | 2010-07-21 | — | — | EP | disclosed |
| WO-2009040702-A2 | PHARMACEUTICAL COMPOSITIONS OF RHEIN OR DIACEREIN | WOCKHARDT RESEARCH CENTRE (IN) | 2009-04-02 | — | — | WO | disclosed |
| WO-2009040776-A1 | SELF-EMULSIFYING PHARMACEUTICAL COMPOSITIONS OF RHEIN OR DIACEREIN | WOCKHARDT RESEARCH CENTRE (IN) | 2009-04-02 | — | — | WO | disclosed |
| WO-2009034409-A2 | PHARMACEUTICAL COMPOSITIONS OF RHEIN OR DIACEREIN | WOCKHARDT RESEARCH CENTRE (IN) | 2009-03-19 | — | — | WO | disclosed |
| WO-2009034558-A2 | RHEIN OR DIACEREIN COMPOSITIONS | WOCKHARDT RESEARCH CENTRE (IN) | 2009-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10154984-B2 | Diacerein or Rhein topical formulations and uses thereof | RFTN1, LRAT, RDX | ALDH1A1 4155/4885MAPT 1042/4885KDM4E 4735/4885 |
| US-10675260-B2 | Methods and pharmaceutical compositions for preventing or treating immunoinflammatory dermal disorders | TSLP, CUTA, MMP1 | ALDH1A1 743/4885MAPT 1373/4885KDM4E 3673/4885 |
| US-20110166225-A1 | ORAL LIQUID COMPOSITIONS OF RHEIN OR DIACEREIN | RCN1, RDX, RPN1 | ALDH1A1 4424/4885MAPT 2616/4885KDM4E 4347/4885 |
| US-10195170-B2 | Methods for inhibiting expression of ASC, expression of NLRP3, and/or formation of NLRP3 inflammasome complex using diacerein or its analogs | PYCARD, NLRP3, NOD1 | ALDH1A1 3674/4885MAPT 1336/4885KDM4E 4530/4885 |
| US-20100303902-A1 | SELF-EMULSIFYING PHARMACEUTICAL COMPOSITIONS OF RHEIN OR DIACEREIN | SI, RDX, CETP | ALDH1A1 3544/4885MAPT 3329/4885KDM4E 3517/4885 |
| US-20100285114-A1 | PHARMACEUTICAL COMPOSITIONS OF RHEIN OR DIACEREIN | SI, HDAC10, RDX | ALDH1A1 3719/4885MAPT 3622/4885KDM4E 3283/4885 |
| US-20190105296-A1 | DIACEREIN OR RHEIN TOPICAL FORMULATIONS AND USES THEREOF | RFTN1, LRAT, RDX | ALDH1A1 4155/4885MAPT 1042/4885KDM4E 4735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.