Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | DHFR | P00374 | 4/20 | 0.43 |
| ▸ | TYMS | P04818 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9085311 | 0.89 | NAMPT (0.53) | NAMPTDHFRTYMS | |
| SCHEMBL9044536 | 0.87 | NAMPT (0.51) | NAMPTDHFRTYMS | |
| SCHEMBL7836419 | 0.84 | NAMPT (0.56) | NAMPTDHFRTYMS | |
| SCHEMBL8997200 | 0.83 | NAMPT (0.42) | NAMPTDHFRTYMS | |
| SCHEMBL9431448 | 0.82 | NAMPT (0.53) | NAMPTDHFRTYMS | |
| SCHEMBL9439883 | 0.81 | FOLR1 (0.44) | NAMPT | |
| SCHEMBL8997197 | 0.81 | DHFR (0.37) | NAMPTDHFRTYMS | |
| SCHEMBL7843188 | 0.80 | NAMPT (0.57) | NAMPTDHFRTYMS | |
| SCHEMBL8982456 | 0.80 | CYP4A11 (0.48) | NAMPTDHFRTYMS | |
| SCHEMBL8982532 | 0.79 | CYP4A11 (0.45) | NAMPTDHFRTYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0334636-B1 | Pyrrolopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-10-23 | — | — | EP | disclosed |
| US-5539113-A | ANTITUMOR AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-07-23 | — | — | US | disclosed |
| US-5496946-A | Production of pyrrolopyrimidines and intermediates therefor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| US-5349064-A | Production of pyrrolopyrimidines | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-09-20 | — | — | US | disclosed |
| US-5296600-A | Antitumor agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-22 | — | — | US | disclosed |
| US-5106974-A | Antitumor and -carcinogenic agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-04-21 | — | — | US | disclosed |
| US-4997838-A | Antitumor agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-03-05 | — | — | US | disclosed |
| EP-0402903-A1 | Production of pyrrolopyrimidines and intermediates therefor | Takeda Chemical Industries, Ltd. (JP) | 1990-12-19 | — | — | EP | disclosed |