Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 7/20 | 0.60 |
| ▸ | ATIC | P31939 | 3/20 | 0.57 |
| ▸ | DHFR | P00374 | 4/20 | 0.54 |
| ▸ | TYMS | P04818 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9223778 | 0.97 | GART (0.57) | GARTATICDHFR | |
| SCHEMBL12521635 | 0.95 | ATIC (0.61) | GARTATICDHFRTYMS | |
| SCHEMBL8997158 | 0.95 | ATIC (0.61) | GARTATICDHFRTYMS | |
| SCHEMBL9432057 | 0.92 | GART (0.60) | GARTATICDHFRTYMS | |
| SCHEMBL8997257 | 0.92 | GART (0.61) | GARTATICDHFR | |
| SCHEMBL9227067 | 0.92 | ATIC (0.58) | GARTATICDHFRTYMS | |
| SCHEMBL9223785 | 0.90 | GART (0.51) | GARTATICDHFR | |
| SCHEMBL9446110 | 0.89 | ATIC (0.69) | GARTATICDHFRTYMS | |
| SCHEMBL9048275 | 0.86 | GART (0.69) | GARTATICDHFR | |
| SCHEMBL9439358 | 0.86 | GART (0.58) | GARTATIC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997838-A | Antitumor agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-03-05 | — | — | US | claimed |
| EP-0334636-B1 | Pyrrolopyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-10-23 | — | — | EP | disclosed |
| US-5539113-A | ANTITUMOR AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-07-23 | — | — | US | disclosed |
| US-5496946-A | Production of pyrrolopyrimidines and intermediates therefor | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-05 | — | — | US | disclosed |
| US-5349064-A | Production of pyrrolopyrimidines | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-09-20 | — | — | US | disclosed |
| US-5296600-A | Antitumor agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-22 | — | — | US | disclosed |
| US-5106974-A | Antitumor and -carcinogenic agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-04-21 | — | — | US | disclosed |
| US-4997838-A | Antitumor agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1991-03-05 | — | — | US | disclosed |
| EP-0402903-A1 | Production of pyrrolopyrimidines and intermediates therefor | Takeda Chemical Industries, Ltd. (JP) | 1990-12-19 | — | — | EP | disclosed |
| EP-0334636-A2 | Pyrrolopyrimidine derivatives, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1989-09-27 | — | — | EP | disclosed |