Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GART | P22102 | 11/20 | 0.58 |
| ▸ | FOLR1 | P15328 | 11/20 | 0.52 |
| ▸ | ATIC | P31939 | 5/20 | 0.52 |
| ▸ | FOLR2 | P14207 | 4/20 | 0.52 |
| ▸ | SLC46A1 | Q96NT5 | 8/20 | 0.51 |
| ▸ | SLC19A1 | P41440 | 5/20 | 0.51 |
| ▸ | SHMT1 | P34896 | 3/20 | 0.49 |
| ▸ | SHMT2 | P34897 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9439570 | 0.92 | GART (0.58) | GARTFOLR1ATICFOLR2SLC46A1 | |
| SCHEMBL9439574 | 0.87 | GART (0.62) | GARTFOLR1ATICFOLR2SLC46A1 | |
| SCHEMBL9001769 | 0.86 | FOLR1 (0.49) | GARTFOLR1ATICFOLR2SLC46A1 | |
| SCHEMBL8997205 | 0.86 | GART (0.60) | GARTATIC | |
| SCHEMBL9859644 | 0.85 | GART (0.42) | GARTFOLR1ATICFOLR2SLC46A1 | |
| SCHEMBL9859650 | 0.85 | GART (0.42) | GARTFOLR1ATICFOLR2SLC46A1 | |
| SCHEMBL9042885 | 0.84 | GART (0.48) | GARTFOLR1ATICFOLR2SLC46A1 | |
| SCHEMBL9380609 | 0.84 | DHFR (0.59) | GARTFOLR1ATICFOLR2SLC46A1 | |
| SCHEMBL9381796 | 0.84 | DHFR (0.59) | GARTFOLR1ATICFOLR2SLC46A1 | |
| SCHEMBL9383067 | 0.84 | DHFR (0.59) | GARTFOLR1ATICFOLR2SLC46A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5354754-A | Antitumor and -carcinogenic agents; treating human epidermoid carcinoma KB | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-10-11 | — | — | US | disclosed |