Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | MPI | P34949 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | CASP2 | P42575 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21083999 | 0.84 | SPHK1 (0.46) | SPHK1CTSDHDAC3HDAC1HDAC2 | |
| SCHEMBL20221443 | 0.83 | SPHK1 (0.45) | SPHK1CTSDHDAC3HDAC1HDAC2 | |
| SCHEMBL1131711 | 0.75 | SPHK1 (0.55) | SPHK1LMNAKDM4EKMT2AEPHX2 | |
| SCHEMBL12589497 | 0.72 | SPHK1 (0.44) | SPHK1KDM4EKMT2A | |
| SCHEMBL8997317 | 0.72 | CTSS (0.35) | CTSDHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL2086150 | 0.70 | KMT2A (0.38) | KDM4EKMT2A | |
| SCHEMBL21083751 | 0.69 | SPHK1 (0.38) | SPHK1LMNAKDM4EKMT2A | |
| SCHEMBL30389190 | 0.68 | SPHK1 (0.37) | SPHK1LMNAKDM4EKMT2AL3MBTL1 | |
| SCHEMBL15116522 | 0.67 | LMNA (0.46) | SPHK1CTSDHDAC3HDAC1HDAC2 | |
| SCHEMBL13502740 | 0.67 | SPHK1 (0.37) | SPHK1CTSDKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5512681-A | HORMONE INHIBITORS FOR TREATMENT OF HYPERTENSION OR CONGESTIVE HEART FAILURE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1996-04-30 | — | — | US | disclosed |
| EP-0601039-A1 | ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLINONE DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1994-06-15 | — | — | EP | disclosed |
| WO-1993004046-A1 | ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLINONE DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-03-04 | — | — | WO | disclosed |