Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5673421 | 0.88 | CTSS (0.40) | CTSSHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL14842066 | 0.75 | CTSL (0.36) | CTSSCTSKCTSL | |
| SCHEMBL3372481 | 0.75 | ALDH1A1 (0.41) | ALDH1A1TDP1RXFP1NPC1RAB9A | |
| SCHEMBL11972690 | 0.75 | EPHX2 (0.51) | — | |
| SCHEMBL21125643 | 0.75 | ANO1 (0.37) | CTSSHDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL15427227 | 0.73 | CTSS (0.42) | CTSSCTSKALDH1A1TDP1CTSL | |
| SCHEMBL8997311 | 0.72 | SPHK1 (0.43) | HDAC3HDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL21125312 | 0.72 | EPHX2 (0.38) | CTSSALDH1A1CTSLNPC1RAB9A | |
| SCHEMBL27991912 | 0.70 | KDM4E (0.45) | ALDH1A1TDP1POLBRXFP1NPC1 | |
| SCHEMBL18910044 | 0.70 | CTSL (0.44) | CTSSCTSKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5512681-A | HORMONE INHIBITORS FOR TREATMENT OF HYPERTENSION OR CONGESTIVE HEART FAILURE | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1996-04-30 | — | — | US | disclosed |
| EP-0601039-A1 | ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLINONE DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1994-06-15 | — | — | EP | disclosed |
| WO-1993004046-A1 | ANGIOTENSIN II RECEPTOR BLOCKING IMIDAZOLINONE DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1993-03-04 | — | — | WO | disclosed |