Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.32 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7890511 | 0.85 | HRH3 (0.39) | HRH3CYP11B1CYP11B2RAPGEF4HTR1D | |
| SCHEMBL2092495 | 0.79 | HRH3 (0.31) | HRH3 | |
| SCHEMBL5702537 | 0.79 | HRH3 (0.35) | HRH3CYP11B1CYP11B2RAPGEF4HTR1D | |
| SCHEMBL2091194 | 0.77 | SLC22A12 (0.36) | HTR1D | |
| SCHEMBL29083610 | 0.77 | HRH3 (0.34) | HRH3CYP11B1CYP11B2RAPGEF4HTR1D | |
| SCHEMBL29083597 | 0.77 | HRH3 (0.34) | HRH3CYP11B1CYP11B2RAPGEF4HTR1D | |
| SCHEMBL18092255 | 0.77 | KMT2A (0.33) | HRH3CYP11B1CYP11B2 | |
| SCHEMBL16542347 | 0.77 | L3MBTL1 (0.32) | HRH3CYP11B1CYP11B2 | |
| SCHEMBL6142873 | 0.76 | CYP11B1 (0.38) | HRH3CYP11B1CYP11B2RAPGEF4HTR1D | |
| SCHEMBL18092254 | 0.76 | PTPN1 (0.35) | HRH3CYP11B1CYP11B2RAPGEF4HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0500621-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE DIURETIC AGENTS | Pfizer Limited (GB) | 1992-09-02 | — | — | EP | claimed |
| WO-1991010644-A1 | CYCLOALKYL-SUBSTITUTED GLUTARAMIDE DIURETIC AGENTS | PFIZER LIMITED (GB) | 1991-07-25 | — | — | WO | claimed |
| EP-0728144-A1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES | Chiroscience Limited (GB) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995013289-A1 | PEPTIDYL COMPOUNDS AND THEIR THERAPEUTIC USE AS INHIBITORS OF METALLOPROTEINASES | CHIROSCIENCE LIMITED (GB) | 1995-05-18 | — | — | WO | disclosed |
| EP-0602025-A1 | N-(1-(2-CARBOXYETHYL)CYCLOALKYL CARBONYL)-BETA-ALANINE DERIVATIVES FOR PHARMACEUTICAL USE | Pfizer Limited (GB) | 1994-06-22 | — | — | EP | disclosed |