Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 9/20 | 0.46 |
| ▸ | MAOA | P21397 | 7/20 | 0.46 |
| ▸ | KDM1A | O60341 | 7/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.46 |
| ▸ | CYP2B6 | P20813 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28168522 | 1.00 | NPC1 (0.47) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| SCHEMBL27482870 | 0.80 | DPP4 (0.44) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| SCHEMBL27483250 | 0.80 | DPP4 (0.44) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| SCHEMBL27527180 | 0.80 | DPP4 (0.44) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| Ethoxycarbonyl Group SCHEMBL28021640 | 0.80 | KDM4E (0.41) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| SCHEMBL12504880 | 0.79 | ALDH1A1 (0.41) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| SCHEMBL24868506 | 0.78 | ALDH1A1 (0.42) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| SCHEMBL12143649 | 0.78 | ALDH1A1 (0.42) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| SCHEMBL19013047 | 0.78 | ALDH1A1 (0.42) | NPC1ALDH1A1MAPTRAB9AKMT2A | |
| SCHEMBL369985 | 0.78 | ALDH1A1 (0.42) | NPC1ALDH1A1MAPTRAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3981395-A1 | LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE DISORDERS | Oryzon Genomics, S.A. (ES) | 2022-04-13 | — | — | EP | claimed |
| EP-2750671-A2 | LYSINE DEMETHYLASE INHIBITORS FOR THROMBOSIS AND CARDIOVASCULAR DISEASES | Oryzon Genomics, S.A. (ES) | 2014-07-09 | — | — | EP | claimed |
| WO-2012156537-A2 | LYSINE DEMETHYLASE INHIBITORS FOR THROMBOSIS AND CARDIOVASCULAR DISEASES | ORYZON GENOMICS, S.A. (ES) | 2012-11-22 | — | — | WO | claimed |
| EP-3981395-A1 | LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE DISORDERS | Oryzon Genomics, S.A. (ES) | 2022-04-13 | — | — | EP | disclosed |
| EP-2712315-B1 | LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE DISORDERS | ORYZON GENOMICS SA (ES) | 2021-11-24 | — | — | EP | disclosed |
| US-9908859-B2 | Lysine demethylase inhibitors for myeloproliferative disorders | ORYZON GENOMICS, S.A. (ES) | 2018-03-06 | — | — | US | disclosed |
| US-9790196-B2 | Lysine demethylase inhibitors for diseases and disorders associated with Flaviviridae | ORYZON GENOMICS S.A. (ES) | 2017-10-17 | — | — | US | disclosed |
| CN-107106517-A | Compositions for modulating cancer stem cells and uses thereof | 堪培拉大学 | 2017-08-29 | — | — | CN | disclosed |
| US-20170209432-A1 | LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE OR LYMPHOPROLIFERATIVE DISEASES OR DISORDERS | ORYZON GENOMICS SA (ES) | 2017-07-27 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| US-9556201-B2 | Bicyclic pyridines and analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-01-31 | — | — | US | disclosed |
| WO-2012156531-A2 | LYSINE DEMETHYLASE INHIBITORS FOR INFLAMMATORY DISEASES OR CONDITIONS | ORYZON GENOMICS, S.A. (ES) | 2012-11-22 | — | — | WO | disclosed |
| CN-102725291-A | Bicyclic pyridines and analogs as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2012-10-10 | — | — | CN | disclosed |
| US-20120252780-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2012-10-04 | — | — | US | disclosed |
| US-20120252780-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2012-10-04 | — | — | US | disclosed |
| EP-2493888-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2012-09-05 | — | — | EP | disclosed |
| WO-2012107499-A1 | LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE OR LYMPHOPROLIFERATIVE DISEASES OR DISORDERS | ORYZON GENOMICS S.A. (ES) | 2012-08-16 | — | — | WO | disclosed |
| WO-2012072713-A2 | LYSINE DEMETHYLASE INHIBITORS FOR DISEASES AND DISORDERS ASSOCIATED WITH FLAVIVIRIDAE | ORYZON GENOMICS, S.A. (ES) | 2012-06-07 | — | — | WO | disclosed |
| WO-2012042042-A1 | SELECTIVE LSD1 AND DUAL LSD1/MAO-B INHIBITORS FOR MODULATING DISEASES ASSOCIATED WITH ALTERATIONS IN PROTEIN CONFORMATION | ORYZON GENOMICS S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |
| WO-2011059839-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2011-05-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120252780-A1 | BICYCLIC PYRIDINES AND ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | NPC1 3795/4885ALDH1A1 2260/4885MAPT 795/4885 |
| US-20170209432-A1 | LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE OR LYMPHOPROLIFERATIVE DISEASES OR DISORDERS | KDM1B, KDM1A, KDM2A | NPC1 2233/4885ALDH1A1 1637/4885MAPT 3526/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.