Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.55 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.53 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SNCA | P37840 | 1/20 | 0.45 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.44 |
| ▸ | CPT1A | P50416 | 1/20 | 0.44 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8528458 | 0.85 | GPR84 (0.73) | GPR84CYSLTR2CYSLTR1MEN1KMT2A | |
| SCHEMBL9669804 | 0.82 | TDP1 (0.48) | GPR84TDP1TRPV1MEN1KMT2A | |
| SCHEMBL8951494 | 0.82 | CYSLTR2 (0.59) | GPR84CYSLTR2CYSLTR1 | |
| SCHEMBL10765512 | 0.82 | GPR84 (0.55) | GPR84CYSLTR2CYSLTR1TDP1TRPV1 | |
| SCHEMBL9669701 | 0.81 | GPR84 (0.57) | GPR84CYSLTR2CYSLTR1TRPV1MEN1 | |
| SCHEMBL8427130 | 0.81 | GPR84 (0.67) | GPR84CYSLTR2CYSLTR1CPT1ACPT1B | |
| SCHEMBL9669799 | 0.81 | CYSLTR1 (0.55) | CYSLTR2CYSLTR1 | |
| SCHEMBL8951119 | 0.79 | CYSLTR1 (0.73) | GPR84CYSLTR2CYSLTR1TDP1MEN1 | |
| SCHEMBL9667839 | 0.79 | TDP1 (0.43) | GPR84TDP1TRPV1MEN1KMT2A | |
| SCHEMBL27273115 | 0.78 | GPR84 (0.63) | GPR84CYSLTR2CYSLTR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0227241-B1 | Medicinal indole and indazole keto sulphone derivatives | ZENECA INC (US) | 1996-09-11 | — | — | EP | disclosed |
| EP-0220066-B1 | CARBOXAMIDE DERIVATIVES | ICI AMERICAS INC. (US) | 1992-03-25 | — | — | EP | disclosed |
| US-5049679-A | Leukotriene antagonists | ICI AMERICAS INC. (US) | 1991-09-17 | — | — | US | disclosed |
| US-5049576-A | Leukotriene antagonists | ICI AMERICAS INC. (US) | 1991-09-17 | — | — | US | disclosed |
| US-4918094-A | Carboxamide derivatives of indoles and leucotriene antagonizing use thereof | ICI AMERICAS INC. (US) | 1990-04-17 | — | — | US | disclosed |
| US-4837235-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | ICI AMERICAS INC. (US) | 1989-06-06 | — | — | US | disclosed |
| EP-0227241-A2 | Medicinal indole and indazole keto sulphone derivatives | ZENECA INC. (US) | 1987-07-01 | — | — | EP | disclosed |
| EP-0220066-A2 | Carboxamide derivatives | ICI AMERICAS INC. (US) | 1987-04-29 | — | — | EP | disclosed |