Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 2/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9669740 | 0.93 | TDP1 (0.48) | TDP1HTR4TRPV1ROCK2ROCK1 | |
| SCHEMBL8998195 | 0.87 | TDP1 (0.42) | TDP1HTR4TRPV1ROCK2ROCK1 | |
| SCHEMBL9669675 | 0.86 | ALDH1A1 (0.42) | TDP1HTR4TRPV1ROCK2ROCK1 | |
| SCHEMBL9667839 | 0.86 | TDP1 (0.43) | TDP1HTR4TRPV1ROCK2ROCK1 | |
| SCHEMBL8532689 | 0.85 | GPR84 (0.49) | TRPV1ALDH1A1MEN1KMT2AGPR84 | |
| SCHEMBL10770909 | 0.85 | TDP1 (0.42) | TDP1HTR4TRPV1ROCK2ROCK1 | |
| SCHEMBL10469556 | 0.84 | CYSLTR2 (0.44) | TDP1PDE4DMAPK14MEN1KMT2A | |
| SCHEMBL9668038 | 0.84 | TDP1 (0.46) | TDP1ROCK2ROCK1ALDH1A1LMNA | |
| SCHEMBL9669728 | 0.84 | GPR84 (0.39) | TRPV1ROCK2MEN1KMT2AGPR84 | |
| SCHEMBL9669643 | 0.84 | KMT2A (0.46) | TRPV1LMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0220066-B1 | CARBOXAMIDE DERIVATIVES | ICI AMERICAS INC. (US) | 1992-03-25 | — | — | EP | disclosed |
| US-5049679-A | Leukotriene antagonists | ICI AMERICAS INC. (US) | 1991-09-17 | — | — | US | disclosed |
| US-5049576-A | Leukotriene antagonists | ICI AMERICAS INC. (US) | 1991-09-17 | — | — | US | disclosed |
| US-4918094-A | Carboxamide derivatives of indoles and leucotriene antagonizing use thereof | ICI AMERICAS INC. (US) | 1990-04-17 | — | — | US | disclosed |
| EP-0220066-A2 | Carboxamide derivatives | ICI AMERICAS INC. (US) | 1987-04-29 | — | — | EP | disclosed |