SCHEMBL899889

SCHEMBL899889

CCN(C(C)=O)c1cccc(C(=O)C=CN(C)C)c1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 12/20 0.56
ALDH1A1 P00352 11/20 0.56
HTT P42858 4/20 0.56
GAA P10253 3/20 0.56
HPGD P15428 3/20 0.56
RECQL P46063 2/20 0.53
RAB9A P51151 5/20 0.51
NPC1 O15118 3/20 0.49
KMT2A Q03164 2/20 0.49
LMNA P02545 4/20 0.45
CYP1A2 P05177 2/20 0.43
CYP2C19 P33261 2/20 0.43
ALOX12 P18054 1/20 0.43
TDP1 Q9NUW8 2/20 0.42
SMN1; SMN2 Q16637 3/20 0.42
POLB P06746 3/20 0.42
HSP90AA1 P07900 1/20 0.42
MEN1 O00255 1/20 0.40
ALPG P10696 1/20 0.40
ATM Q13315 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31531972 1.00 MAPT (0.56) MAPTALDH1A1HTTGAAHPGD
SCHEMBL3162509 1.00 MAPT (0.56) MAPTALDH1A1HTTGAAHPGD
Hydrochloric Acid SCHEMBL4078663 0.99 MAPT (0.55) MAPTALDH1A1HTTGAAHPGD
Hydrochloric Acid SCHEMBL4071405 0.99 MAPT (0.55) MAPTALDH1A1HTTGAAHPGD
SCHEMBL5536634 0.90 MAPT (0.53) MAPTALDH1A1HTTGAAHPGD
SCHEMBL5536639 0.90 MAPT (0.53) MAPTALDH1A1HTTGAAHPGD
SCHEMBL9530442 0.89 RECQL (0.56) MAPTALDH1A1HTTGAAHPGD
SCHEMBL9529227 0.89 RECQL (0.56) MAPTALDH1A1HTTGAAHPGD
SCHEMBL7366776 0.88 MAPT (0.55) MAPTALDH1A1HTTGAAHPGD
SCHEMBL7366780 0.88 MAPT (0.55) MAPTALDH1A1HTTGAAHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 124 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117143281-A Acid gas trigger tracer slow-release gel material and preparation method and application thereof 中国科学院长春应用化学研究所 2023-12-01 CN claimed
EP-1713808-B1 TWO-PHASE METHOD FOR THE SYNTHESIS OF SELECTED PYRAZOLOPYRIMIDINES MALLINCKRODT INC (US) 2010-02-24 EP claimed
US-20090247751-A1 PROCESS FOR THE PREPARATION OF ZALEPLON AND AN INTERMEDIATE THEREOF PIRAMAL HEALTHCARE LIMITED (IN) 2009-10-01 US claimed
EP-1950213-B1 N-{3-[3-(dimethylamino)-1-oxo-2-propenyl]phenyl}-N-ethyl-acetamide hydrochloride RICHTER GEDEON NYRT (HU) 2009-08-05 EP claimed
US-7498434-B2 Two-phase method for the synthesis of selected pyrazolopyrimidines MALLINCKRODT INC (US) 2009-03-03 US claimed
EP-1711501-B1 PROCESS FOR THE SYNTHESIS OF N- [3-(3-CYANOPYRAZOLO [1,5A] PYRIMIDIN-7-YL)-PHENYL] -N-ETHYL-ACETAMIDE RICHTER GEDEON NYRT (HU) 2009-01-14 EP claimed
EP-2004650-A2 PROCESS FOR THE PREPARATION OF ZALEPLON AND AN INTERMEDIATE THEREOF Piramal Healthcare Limited (IN) 2008-12-24 EP claimed
EP-1950213-A2 Process for the synthesis of N-[3- (3-cyanopyrazolo [1,5a] pyrimidin-7-yl) -phnyl] -N-ethyl-acetamide Richter Gedeon Vegyészeti Gyár R.T. (HU) 2008-07-30 EP claimed
EP-1554279-B1 PROCESS FOR THE PREPARATION OF ZALEPLON ZENTIVA AS (CZ) 2007-11-28 EP claimed
WO-2007096807-A9 PROCESS FOR THE PREPARATION OF ZALEPLON AND AN INTERMEDIATE THEREOF NICHOLAS PIRAMAL INDIA LTD (IN) 2007-11-22 WO claimed
EP-1406871-A4 PROCESS FOR THE PRODUCTION OF N- 3-(3-CYANOPYRAZOLO 1,5-A] PYRIMIDIN-7-YL)PHENYL]-N-ETHYLACETAMIDE (ZALEPLON) BIOGAL GYOGYSZERGYAR (HU) 2005-01-26 EP claimed
EP-1430054-A2 PURIFICATION AND CRYSTALLINE FORMS OF ZALEPLON BIOGAL GYOGYSZERGYAR RT. (HU) 2004-06-23 EP claimed
WO-2004037824-A1 PROCESS FOR THE PREPARATION OF ZALEPLON ZENTIVA, A.S. (CZ) 2004-05-06 WO claimed
EP-1406871-A2 PROCESS FOR THE PRODUCTION OF N- 3-(3-CYANOPYRAZOLO 1,5-A] PYRIMIDIN-7-YL)PHENYL]-N-ETHYLACETAMIDE (ZALEPLON) BIOGAL GYOGYSZERGYAR RT. (HU) 2004-04-14 EP claimed
US-20030130291-A1 Process for purifying N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (zaleplon) and crystalline forms of zaleplon accessible with the process TEVA GYOGYSZERGYAR ZARTKORUEN MUKODO RESZVENYTARSASAG (HU) 2003-07-10 US claimed
US-20030040522-A1 Process for the production of N-[3-(3-cyanopyrazolo[1,5-a] pyrimidin-7-yl) phenyl]-N-ethylacetamide (zaleplon) TEVA GYOGYSZERGYAR ZARTKORUEN MUKODO RESZVENYTARSASAG (HU) 2003-02-27 US claimed
WO-2003011228-A2 PURIFICATION AND CRYSTALLINE FORMS OF ZALEPLON BIOGAL GYOGYSZERGYAR RT (HU) 2003-02-13 WO claimed
WO-2002100828-A2 PROCESS FOR THE PRODUCTION OF ZALEPLON BIOGAL GYOGYSZERGYAR RT (HU) 2002-12-19 WO claimed
US-6476223-B2 REACTING N-(3-(3-(DIMETHYLAMINE)-OXO-2-PROPENYL)PHENYL) ACETAMIDE WITH ETHYL IODIDE IN THE PRESENCE OF SODIUM HYDRIDE IN DIMETHYLFORMAMIDE; DILUTING (N-(3-(3-(DIMETHYLAMINE)-1-OXO-2-PROPENYL)ACETAMIDE GADOR S. A. (AR) 2002-11-05 US claimed
US-20020072605-A1 Method for obtaining N-[3(3-cyano-pyrazole[1,5-a]pyrimidine-7-yl)phenyl]-N-ethyl-acetamide GADOR S.A. (AR) 2002-06-13 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030130291-A1 Process for purifying N-[3-(3-cyanopyrazolo[1,5-a]pyrimidin-7-yl)phenyl]-N-ethylacetamide (zaleplon) and crystalline forms of zaleplon accessible with the process NPEPPS, CPN1, AZI2 MAPT 3333/4885ALDH1A1 1809/4885HTT 2686/4885
US-20020072605-A1 Method for obtaining N-[3(3-cyano-pyrazole[1,5-a]pyrimidine-7-yl)phenyl]-N-ethyl-acetamide DPYD, IDH3A, POLL MAPT 4232/4885ALDH1A1 126/4885HTT 1744/4885
US-20090247751-A1 PROCESS FOR THE PREPARATION OF ZALEPLON AND AN INTERMEDIATE THEREOF SLC30A6, SLC30A7, SLC39A3 MAPT 3251/4885ALDH1A1 419/4885HTT 3093/4885
US-20030040522-A1 Process for the production of N-[3-(3-cyanopyrazolo[1,5-a] pyrimidin-7-yl) phenyl]-N-ethylacetamide (zaleplon) AANAT, NPEPPS, CYP51A1 MAPT 1097/4885ALDH1A1 1576/4885HTT 3066/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.