Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | BRS3 | P32247 | 8/20 | 0.63 |
| ▸ | NMBR | P28336 | 5/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8999025 | 0.93 | KMT2A (0.64) | KMT2AMEN1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL8998993 | 0.89 | KCNT1 (0.60) | KMT2AMEN1KDM4EALDH1A1CYP3A4 | |
| Hydrochloric Acid SCHEMBL9833815 | 0.86 | HDAC8 (0.66) | KMT2AMEN1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL6892616 | 0.85 | KMT2A (0.83) | KMT2AMEN1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL8706463 | 0.85 | KMT2A (0.65) | KMT2AMEN1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL8893203 | 0.85 | KMT2A (0.65) | KMT2AMEN1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL6894596 | 0.85 | KMT2A (0.65) | KMT2AMEN1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL1388421 | 0.82 | KCNT1 (0.60) | KMT2AMEN1KDM4EALDH1A1CYP3A4 | |
| SCHEMBL8999037 | 0.80 | KDM4E (0.57) | KMT2AMEN1KDM4EMAPTALOX15 | |
| SCHEMBL27763689 | 0.80 | BRS3 (0.85) | KMT2ABRS3NMBRHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5556874-A | ENZYME INHIBITORS AS ANTICARCINOGENIC AGENTS | WARNER LAMBERT COMPANY (US) | 1996-09-17 | — | — | US | disclosed |
| US-5464861-A | Anticarcinogenic agents | WARNER-LAMBERT (US) | 1995-11-07 | — | — | US | disclosed |
| EP-0654024-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003427-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1994-02-17 | — | — | WO | disclosed |