Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | APAF1 | O14727 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MMP9 | P14780 | 8/20 | 0.56 |
| ▸ | MMP8 | P22894 | 8/20 | 0.56 |
| ▸ | MMP1 | P03956 | 4/20 | 0.56 |
| ▸ | MMP3 | P08254 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MMP2 | P08253 | 7/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MPO | P05164 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8999397 | 0.92 | KDM4E (0.57) | KDM4EMAPTPOLBAPAF1RECQL | |
| SCHEMBL8999082 | 0.86 | KMT2A (0.53) | KDM4EMAPTPOLBAPAF1RECQL | |
| Hydrochloric Acid SCHEMBL8398299 | 0.84 | KDM4E (0.68) | KDM4EMAPTPOLBAPAF1RECQL | |
| Hydrochloric Acid SCHEMBL6044250 | 0.84 | MMP9 (0.65) | KDM4EMAPTPOLBAPAF1RECQL | |
| Hydrochloric Acid SCHEMBL6044254 | 0.84 | MMP9 (0.65) | KDM4EMAPTPOLBAPAF1RECQL | |
| Hydrochloric Acid SCHEMBL27780592 | 0.84 | KDM4E (0.68) | KDM4EMAPTPOLBAPAF1RECQL | |
| SCHEMBL20713624 | 0.83 | POLB (0.72) | KDM4EMAPTPOLBAPAF1RECQL | |
| SCHEMBL8998993 | 0.83 | KCNT1 (0.60) | KDM4EMAPTPOLBAPAF1RECQL | |
| SCHEMBL16182036 | 0.82 | MMP9 (0.66) | KDM4EMAPTPOLBAPAF1RECQL | |
| SCHEMBL876693 | 0.82 | KDM4E (0.70) | KDM4EMAPTPOLBAPAF1RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5556874-A | ENZYME INHIBITORS AS ANTICARCINOGENIC AGENTS | WARNER LAMBERT COMPANY (US) | 1996-09-17 | — | — | US | disclosed |
| US-5464861-A | Anticarcinogenic agents | WARNER-LAMBERT (US) | 1995-11-07 | — | — | US | disclosed |
| EP-0654024-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003427-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1994-02-17 | — | — | WO | disclosed |