Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.74 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.60 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.60 |
| ▸ | TNFSF11 | O14788 | 4/20 | 0.57 |
| ▸ | TNF | P01375 | 6/20 | 0.55 |
| ▸ | HTR6 | P50406 | 6/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13485750 | 0.86 | PLK1 (0.78) | PLK1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL8999130 | 0.85 | PLK1 (1.00) | PLK1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL949716 | 0.83 | LMNA (1.00) | PLK1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL30393652 | 0.83 | LMNA (1.00) | PLK1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL948989 | 0.83 | AKR1C3 (0.83) | PLK1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL8998767 | 0.82 | PLK1 (0.74) | PLK1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL4926276 | 0.80 | LMNA (0.74) | PLK1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL8998784 | 0.80 | LMNA (0.74) | PLK1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL2886421 | 0.80 | KMT2A (1.00) | PLK1LMNASMN1; SMN2MEN1KMT2A | |
| SCHEMBL13797646 | 0.79 | PLK1 (0.53) | PLK1LMNASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5556874-A | ENZYME INHIBITORS AS ANTICARCINOGENIC AGENTS | WARNER LAMBERT COMPANY (US) | 1996-09-17 | — | — | US | disclosed |
| US-5464861-A | Anticarcinogenic agents | WARNER-LAMBERT (US) | 1995-11-07 | — | — | US | disclosed |
| EP-0654024-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003427-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1994-02-17 | — | — | WO | disclosed |