Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MITF | O75030 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | BCHE | P06276 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9157388 | 0.87 | HDAC1 (0.61) | EGFRHDAC1HDAC2LMNAPOLB | |
| SCHEMBL23940250 | 0.82 | BRD4 (0.71) | HDAC1HDAC2LMNAPOLBALDH1A1 | |
| SCHEMBL23940245 | 0.80 | ALDH1A1 (0.83) | HDAC1HDAC2LMNAALDH1A1KDM4E | |
| SCHEMBL28968558 | 0.80 | HDAC1 (0.58) | HDAC1HDAC2LMNAPOLBALDH1A1 | |
| SCHEMBL23940148 | 0.79 | HDAC1 (0.65) | HDAC1HDAC2LMNAPOLBALDH1A1 | |
| SCHEMBL6586386 | 0.76 | NR4A2 (0.64) | HDAC1HDAC2LMNAPOLBALDH1A1 | |
| SCHEMBL23940223 | 0.76 | HDAC1 (0.57) | HDAC1HDAC2LMNAPOLBALDH1A1 | |
| SCHEMBL4104715 | 0.76 | ALDH1A1 (0.64) | HDAC1HDAC2LMNAPOLBALDH1A1 | |
| SCHEMBL1388406 | 0.75 | EGFR (1.00) | EGFRLMNAPOLBALDH1A1KDM4E | |
| SCHEMBL23940201 | 0.75 | HDAC1 (0.56) | HDAC1HDAC2LMNAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5556874-A | ENZYME INHIBITORS AS ANTICARCINOGENIC AGENTS | WARNER LAMBERT COMPANY (US) | 1996-09-17 | — | — | US | disclosed |
| US-5464861-A | Anticarcinogenic agents | WARNER-LAMBERT (US) | 1995-11-07 | — | — | US | disclosed |