Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.62 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | MITF | O75030 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4104715 | 0.87 | ALDH1A1 (0.64) | ALDH1A1KDM4EHDAC1HDAC2NR4A2 | |
| SCHEMBL23940243 | 0.83 | ALDH1A1 (0.59) | ALDH1A1KDM4EHDAC1HDAC2KMT2A | |
| SCHEMBL23940250 | 0.82 | BRD4 (0.71) | ALDH1A1HDAC1HDAC2NR4A2LMNA | |
| SCHEMBL9157388 | 0.82 | HDAC1 (0.61) | ALDH1A1KDM4EHDAC1HDAC2NR4A2 | |
| SCHEMBL23940148 | 0.82 | HDAC1 (0.65) | ALDH1A1HDAC1HDAC2NR4A2LMNA | |
| SCHEMBL442523 | 0.81 | ALDH1A1 (0.57) | ALDH1A1HDAC1HDAC2LMNAKMT2A | |
| SCHEMBL8999213 | 0.80 | EGFR (0.60) | ALDH1A1KDM4EHDAC1HDAC2NR4A2 | |
| SCHEMBL28968558 | 0.80 | HDAC1 (0.58) | ALDH1A1HDAC1HDAC2NR4A2LMNA | |
| SCHEMBL27249579 | 0.80 | LMNA (0.64) | ALDH1A1KDM4EHDAC1HDAC2NR4A2 | |
| SCHEMBL4253166 | 0.79 | ALDH1A1 (0.55) | ALDH1A1KDM4EHDAC1HDAC2NR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210323966-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210323966-A1 | IMIDAZOPYRIDAZINE COMPOUNDS | TYK2, JAK3, JAK1 | ALDH1A1 2637/4885KDM4E 2484/4885HDAC1 714/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.