Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 17/20 | 0.75 |
| ▸ | EGFR | P00533 | 13/20 | 0.75 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.75 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8998978 | 0.87 | NPC1 (0.74) | SRCEGFRFGFR1NPC1ALDH1A1 | |
| SCHEMBL8998915 | 0.86 | SRC (0.81) | SRCEGFRFGFR1NPC1ALDH1A1 | |
| SCHEMBL1527703 | 0.86 | SRC (1.00) | SRCEGFRFGFR1NPC1ALDH1A1 | |
| SCHEMBL10676012 | 0.82 | RAB9A (0.71) | NPC1ALDH1A1SMN1; SMN2 | |
| SCHEMBL8998829 | 0.78 | SRC (1.00) | SRCEGFRFGFR1NPC1ALDH1A1 | |
| SCHEMBL8998908 | 0.78 | SRC (1.00) | SRCEGFRFGFR1NPC1ALDH1A1 | |
| SCHEMBL8999067 | 0.78 | SRC (1.00) | SRCEGFRFGFR1 | |
| SCHEMBL8999420 | 0.76 | SRC (1.00) | SRCEGFRFGFR1SMN1; SMN2 | |
| SCHEMBL8999038 | 0.76 | SRC (1.00) | SRCEGFRFGFR1ALDH1A1 | |
| SCHEMBL9165502 | 0.74 | HTR2C (0.61) | NPC1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5556874-A | ENZYME INHIBITORS AS ANTICARCINOGENIC AGENTS | WARNER LAMBERT COMPANY (US) | 1996-09-17 | — | — | US | disclosed |
| EP-0654024-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1995-05-24 | — | — | EP | disclosed |
| WO-1994003427-A1 | 2-THIOINDOLES (SELENOINDOLES) AND RELATED DISULFIDES (SELENIDES) WHICH INHIBIT PROTEIN TYROSINE KINASES AND WHICH HAVE ANTITUMOR PROPERTIES | WARNER-LAMBERT COMPANY (US) | 1994-02-17 | — | — | WO | disclosed |