SCHEMBL8999322

SCHEMBL8999322

CC(C)(c1ccc(Oc2cccc([N+](=O)[O-])c2)cc1)c1ccc(Oc2cccc([N+](=O)[O-])c2)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.54
LTA4H P09960 1/20 0.51
PTGS2 P35354 1/20 0.51
KDM4E B2RXH2 1/20 0.50
CYP2C9 P11712 1/20 0.49
CYP2C19 P33261 1/20 0.49
MEN1 O00255 2/20 0.48
MAPT P10636 2/20 0.48
KMT2A Q03164 2/20 0.48
TSHR P16473 2/20 0.47
LMNA P02545 2/20 0.47
PGR P06401 1/20 0.47
CHRNB2 P17787 1/20 0.47
CHRNA4 P43681 1/20 0.47
LPAR3 Q9UBY5 1/20 0.46
NPY5R Q15761 1/20 0.45
ACHE P22303 1/20 0.45
PTPRC P08575 1/20 0.44
NFE2L2 Q16236 1/20 0.43
FFAR1 O14842 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9082564 1.00 ALDH1A1 (0.54) ALDH1A1LTA4HPTGS2KDM4ECYP2C9
SCHEMBL9081035 0.96 ALDH1A1 (0.50) ALDH1A1LTA4HPTGS2KDM4ECYP2C9
SCHEMBL9356275 0.91 ALDH1A1 (0.46) ALDH1A1LTA4HPTGS2KDM4ECYP2C9
SCHEMBL9356654 0.90 ALDH1A1 (0.45) ALDH1A1LTA4HPTGS2KDM4ECYP2C9
SCHEMBL9158141 0.87 ALDH1A1 (0.67) ALDH1A1LTA4HPTGS2KDM4ECYP2C9
SCHEMBL9356592 0.87 ALDH1A1 (0.67) ALDH1A1LTA4HPTGS2KDM4ECYP2C9
SCHEMBL30334516 0.85 ALDH1A1 (0.54) ALDH1A1LTA4HPTGS2KDM4ECYP2C9
SCHEMBL26215299 0.85 ALDH1A1 (0.54) ALDH1A1LTA4HPTGS2KDM4ECYP2C9
SCHEMBL9082196 0.85 ALDH1A1 (0.54) ALDH1A1KDM4EMEN1MAPTKMT2A
SCHEMBL9497275 0.84 HSPB1 (0.59) ALDH1A1KDM4EMEN1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108191682-B Synthetic method of 2, 2-bis [4- (3-aminophenoxy) phenyl ] propane 常州市阳光药业有限公司 2020-09-22 CN disclosed
CN-1425644-A Process for preparing 2,2-di-[4-(3-nitro phenoxy) phenyl] propane SHANGHAI CITY INST OF SYNTHETI (CN) 2003-06-25 CN disclosed
CN-1425644-A Process for preparing 2,2-di-[4-(3-nitro phenoxy) phenyl] propane SHANGHAI CITY INST OF SYNTHETI (CN) 2003-06-25 CN disclosed
EP-0729995-A1 Polyimide and high-temperature adhesive of polyimide MITSUI TOATSU CHEMICALS, Inc. (JP) 1996-09-04 EP disclosed
EP-0435659-B1 Preparation process of bis(3-nitrophenoxy) compound MITSUI TOATSU CHEMICALS (JP) 1995-02-22 EP disclosed
EP-0192480-B1 Bis(3-aminophenoxy) aromatics and method of preparing the same MITSUI TOATSU CHEMICALS (JP) 1994-11-23 EP disclosed
US-5296635-A Condensing dihydroxydiphenyl compound and meta-dinitrobenzene in aprotic polar solvent with alkali metal carbonate while removing water formed MITSUI TOATSU CHEMICALS, INC. (JP) 1994-03-22 US disclosed
US-5278276-A Polyamic acid precursor; prepared from bis/aminophenoxyphenyl/ compounds and tetracarboxylic acid dianhydrides MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1994-01-11 US disclosed
US-5205894-A High bonding strength MITSUI TOATSU CHEMICALS, INC. (JP) 1993-04-27 US disclosed
EP-0267289-B1 POLYIMIDE RESIN COMPOSITION MITSUI TOATSU CHEMICALS, Inc. (JP) 1993-03-17 EP disclosed
EP-0251741-B1 POLYIMIDE RESIN COMPOSITION MITSUI TOATSU CHEMICALS, Inc. (JP) 1991-08-21 EP disclosed
EP-0435659-A2 Preparation process of bis(3-nitrophenoxy) compound MITSUI TOATSU CHEMICALS, Inc. (JP) 1991-07-03 EP disclosed
US-4847311-A ETHER CONTAINING AMINE, TETRACARBOXYLIC ACID, FIBER REINFORCEMENT MITSUI TOATSU CHEMICALS, INC. (JP) 1989-07-11 US disclosed
US-4847349-A ADHESIVES, HEAT AND SOLVENT RESISTANCE MITSUI TOATSU CHEMICALS, INC. (JP) 1989-07-11 US disclosed
US-4816516-A BLENDS FOR MOLDING MATERIALS MITSUI TOATSU CHEMICALS, INC. (JP) 1989-03-28 US disclosed
EP-0267289-A1 POLYIMIDE RESIN COMPOSITION MITSUI TOATSU CHEMICALS, Inc. (JP) 1988-05-18 EP disclosed
EP-0265825-A2 Use of disinfectants for combating and destroying parasitic latent forms Henkel Kommanditgesellschaft auf Aktien (DE) 1988-05-04 EP disclosed
EP-0251741-A2 Polyimide resin composition MITSUI TOATSU CHEMICALS, Inc. (JP) 1988-01-07 EP disclosed
EP-0235294-A1 POLYIMIDES AND HEAT-RESISTANT ADHESIVES COMPRISING THE SAME MITSUI TOATSU CHEMICALS, Inc. (JP) 1987-09-09 EP disclosed
EP-0192480-A1 Bis(3-aminophenoxy) aromatics and method of preparing the same MITSUI TOATSU CHEMICALS, Inc. (JP) 1986-08-27 EP disclosed