SCHEMBL8999953

SCHEMBL8999953

O=[N+]([O-])c1cc(C(F)(F)F)cc(C(c2cc([N+](=O)[O-])cc(C(F)(F)F)c2)(C(F)(F)F)C(F)(F)F)c1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.47
TSHR P16473 3/20 0.47
CYP3A4 P08684 2/20 0.47
TDP1 Q9NUW8 2/20 0.47
HPGD P15428 1/20 0.47
ALOX15 P16050 1/20 0.47
HIF1A Q16665 1/20 0.47
TXNRD1 Q16881 1/20 0.47
TXNRD3 Q86VQ6 1/20 0.47
TXNRD2 Q9NNW7 1/20 0.47
P2RX1 P51575 4/20 0.41
TMPRSS4 Q9NRS4 1/20 0.41
KIF11 P52732 2/20 0.41
CYP19A1 P11511 1/20 0.40
PTPN5 P54829 1/20 0.40
P2RX4 Q99571 1/20 0.40
P2RX7 Q99572 1/20 0.40
MAPK1 P28482 1/20 0.38
CES2 O00748 1/20 0.36
NOX1 Q9Y5S8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1996062 0.90 ALDH1A1 (0.55) ALDH1A1TSHRCYP3A4TDP1HPGD
SCHEMBL1005841 0.86 TSHR (0.55) ALDH1A1TSHRCYP3A4TDP1HPGD
Hydrochloric Acid SCHEMBL28212666 0.84 TSHR (0.53) ALDH1A1TSHRCYP3A4TDP1HPGD
Hydrazine SCHEMBL28307217 0.82 TSHR (0.52) ALDH1A1TSHRCYP3A4TDP1HPGD
SCHEMBL13343341 0.81 TSHR (0.47) ALDH1A1TSHRCYP3A4TDP1HPGD
SCHEMBL788543 0.79 ALDH1A1 (0.46) ALDH1A1TSHRCYP3A4TDP1HPGD
SCHEMBL30600332 0.78 CYP19A1 (0.64) ALDH1A1TSHRCYP3A4TDP1HPGD
SCHEMBL29658338 0.78 TSHR (0.48) ALDH1A1TSHRCYP3A4TDP1HPGD
SCHEMBL1505899 0.78 TSHR (0.48) ALDH1A1TSHRCYP3A4TDP1HPGD
SCHEMBL29656448 0.78 ALDH1A1 (0.44) ALDH1A1TSHRCYP3A4TDP1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5578697-A DIELECTRIC POLYMERS FOR ELECTRONICS KABUSHIKI KAISHA TOSHIBA (JP) 1996-11-26 US disclosed