Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 11/20 | 0.44 |
| ▸ | ADCY6 | O43306 | 6/20 | 0.44 |
| ▸ | ADCY3 | O60266 | 6/20 | 0.44 |
| ▸ | ADCY9 | O60503 | 6/20 | 0.44 |
| ▸ | ADCY5 | O95622 | 6/20 | 0.44 |
| ▸ | ADCY8 | P40145 | 6/20 | 0.44 |
| ▸ | ADCY7 | P51828 | 6/20 | 0.44 |
| ▸ | ADCY2 | Q08462 | 6/20 | 0.44 |
| ▸ | ADCY1 | Q08828 | 6/20 | 0.44 |
| ▸ | ADCY4 | Q8NFM4 | 6/20 | 0.44 |
| ▸ | SOAT1 | P35610 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000513 | 0.90 | SOAT1 (0.41) | SOAT1ALDH1A1MAPTHDAC3HDAC4 | |
| SCHEMBL9000450 | 0.89 | SOAT1 (0.41) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL9000758 | 0.89 | SOAT1 (0.41) | SOAT1ALDH1A1MAPTHDAC3HDAC4 | |
| SCHEMBL9000599 | 0.88 | SOAT1 (0.40) | SOAT1HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL9000409 | 0.88 | TRPV1 (0.40) | SOAT1MAPT | |
| SCHEMBL9000604 | 0.86 | EPHX1 (0.47) | SOAT1ALDH1A1MAPT | |
| SCHEMBL9000846 | 0.86 | SOAT1 (0.40) | SOAT1MAPTHDAC3HDAC4HDAC1 | |
| SCHEMBL9000798 | 0.84 | QPCT (0.49) | SOAT1ALDH1A1MAPT | |
| SCHEMBL9000785 | 0.83 | PPARG (0.37) | GCGRSOAT1HDAC3HDAC1 | |
| SCHEMBL9000825 | 0.82 | GLI1 (0.39) | SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |