Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 6/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000758 | 0.93 | SOAT1 (0.41) | SOAT1MAPTHDAC3HDAC4HDAC1 | |
| SCHEMBL9000450 | 0.91 | SOAT1 (0.41) | SOAT1MAPTHDAC3HDAC4HDAC1 | |
| SCHEMBL9000612 | 0.90 | GCGR (0.44) | SOAT1MAPTHDAC3HDAC4HDAC1 | |
| SCHEMBL9000599 | 0.89 | SOAT1 (0.40) | SOAT1HDAC3HDAC4HDAC1HDAC8 | |
| SCHEMBL9000409 | 0.89 | TRPV1 (0.40) | SOAT1MAPTL3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL9000846 | 0.89 | SOAT1 (0.40) | SOAT1MAPTHDAC3HDAC4HDAC1 | |
| SCHEMBL9000798 | 0.86 | QPCT (0.49) | SOAT1MAPTLMNAALDH1A1TSHR | |
| SCHEMBL9000506 | 0.84 | SOAT1 (0.39) | SOAT1LMNAALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL9000825 | 0.84 | GLI1 (0.39) | SOAT1 | |
| SCHEMBL9000693 | 0.81 | EPHX1 (0.37) | SOAT1CRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |