Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000409 | 0.89 | TRPV1 (0.40) | MEN1KMT2AMAPTRAB9AFPR2 | |
| SCHEMBL9000513 | 0.86 | SOAT1 (0.41) | MAPTALDH1A1RAB9ALMNASOAT1 | |
| SCHEMBL9000787 | 0.86 | LMNA (0.46) | QPCTMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL9000846 | 0.85 | SOAT1 (0.40) | KCNQ2MEN1KMT2AMAPTLMNA | |
| SCHEMBL9000599 | 0.85 | SOAT1 (0.40) | LMNASOAT1 | |
| SCHEMBL9000450 | 0.85 | SOAT1 (0.41) | MEN1KMT2AMAPTALDH1A1LMNA | |
| SCHEMBL9000758 | 0.85 | SOAT1 (0.41) | MEN1KMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL9000612 | 0.84 | GCGR (0.44) | MAPTALDH1A1SOAT1 | |
| SCHEMBL9000825 | 0.84 | GLI1 (0.39) | MEN1KMT2ASOAT1 | |
| SCHEMBL9000757 | 0.83 | KCNQ2 (0.37) | KCNQ2MEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |