Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9411752 | 0.72 | MAPT (0.49) | MAPTLMNAMDM2KMT2APKM | |
| SCHEMBL8980054 | 0.65 | ALDH1A1 (0.70) | MAPTKMT2APKMKDM4EHTT | |
| SCHEMBL6286103 | 0.65 | SOAT1 (0.41) | KMT2AKDM4EALDH1A1MEN1SOAT1 | |
| SCHEMBL27479697 | 0.65 | NPC1 (0.64) | MAPTLMNAKDM4EHTTHSD17B10 | |
| SCHEMBL7434954 | 0.65 | MAPT (0.42) | MAPTLMNAMDM2KMT2APKM | |
| SCHEMBL9000628 | 0.64 | SOAT1 (0.45) | MAPTLMNAKMT2AHTTHSD17B10 | |
| SCHEMBL32667998 | 0.64 | CYP1A2 (0.50) | KMT2AALDH1A1MEN1SOAT1RAB9A | |
| SCHEMBL9000853 | 0.64 | SOAT1 (0.42) | MAPTLMNAKMT2AKDM4ENPSR1 | |
| SCHEMBL6284260 | 0.63 | ALDH1A1 (0.46) | MAPTKMT2AKDM4EHTTHSD17B10 | |
| SCHEMBL9001010 | 0.63 | SOAT1 (0.43) | LMNAKMT2AKDM4EHTTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |