Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 1/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | PPARA | Q07869 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.36 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9000778 | 0.93 | PPARG (0.40) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9000692 | 0.87 | SOAT1 (0.46) | SOAT1CYSLTR2CYSLTR1 | |
| SCHEMBL9000663 | 0.86 | SOAT1 (0.37) | PPARGPPARASOAT1 | |
| SCHEMBL9000825 | 0.86 | GLI1 (0.39) | SOAT1 | |
| SCHEMBL9000979 | 0.83 | MMP9 (0.38) | PPARGSOAT1 | |
| SCHEMBL9000693 | 0.82 | EPHX1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9000757 | 0.82 | KCNQ2 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9000824 | 0.81 | CDC7 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL9000771 | 0.81 | SOAT1 (0.47) | PPARGPPARASOAT1 | |
| SCHEMBL9000773 | 0.81 | FFAR2 (0.41) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5583147-A | INHIBITORS OF ACYL-COENZYME A: CHOLESTEROL O-TRANSFERASE; ANTIHYPERCHOLESTEROLEMIC AND/OR ANTIATHEROSCLEROTIC AGENTS | THE DUPONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-12-10 | — | — | US | disclosed |