Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.68 |
| ▸ | HTR1D | P28221 | 1/20 | 0.68 |
| ▸ | HTR2B | P41595 | 1/20 | 0.68 |
| ▸ | DRD2 | P14416 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 7/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.53 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
| ▸ | CCR5 | P51681 | 1/20 | 0.49 |
| ▸ | CCR8 | P51685 | 1/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796977 | 0.84 | HTR1A (0.61) | HTR1AHTR1DHTR2BCCR5CCR8 | |
| SCHEMBL8799021 | 0.84 | HTR1A (0.61) | HTR1AHTR1DHTR2BCCR5CCR8 | |
| Hydrochloric Acid SCHEMBL8798496 | 0.84 | HTR1A (0.60) | HTR1AHTR1DHTR2BCCR5CCR8 | |
| SCHEMBL8065712 | 0.81 | HTR1A (1.00) | HTR1AHTR1DHTR2BDRD2ALDH1A1 | |
| SCHEMBL6546383 | 0.81 | HTR1A (1.00) | HTR1AHTR1DHTR2BDRD2ALDH1A1 | |
| Fumaric Acid SCHEMBL8799082 | 0.81 | HTR1A (0.57) | HTR1AHTR1DHTR2BCCR5CCR8 | |
| Fumaric Acid SCHEMBL8799091 | 0.81 | HTR1A (0.57) | HTR1AHTR1DHTR2BCCR5CCR8 | |
| SCHEMBL9001212 | 0.79 | MEN1 (0.58) | HTR1ADRD2MEN1KMT2ACACNA1G | |
| SCHEMBL9001189 | 0.79 | HTR1A (0.50) | HTR1AHTR1DHTR2BMEN1KMT2A | |
| SCHEMBL7937291 | 0.75 | HTR1A (0.62) | HTR1AHTR1DHTR2BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585374-A | Amide derivatives | JOHN WYETH BROTHER, LIMITED (GB) | 1996-12-17 | — | — | US | claimed |
| US-5585374-A | Amide derivatives | JOHN WYETH BROTHER, LIMITED (GB) | 1996-12-17 | — | — | US | disclosed |