SCHEMBL900320

SCHEMBL900320

[CH2]c1nc(N)no1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1389077 0.65
SCHEMBL22576622 0.61
SCHEMBL20433304 0.60
SCHEMBL8006674 0.60
SCHEMBL25241013 0.57
SCHEMBL2182519 0.54
Ethylene SCHEMBL2038444 0.54 LMNA (0.47)
Ethylene SCHEMBL76403 0.54 LMNA (0.47)
Ethylene SCHEMBL11150398 0.54 LMNA (0.47)
SCHEMBL175612 0.51 CASP1 (0.50)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2712315-B1 LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE DISORDERS ORYZON GENOMICS SA (ES) 2021-11-24 EP disclosed
US-9908859-B2 Lysine demethylase inhibitors for myeloproliferative disorders ORYZON GENOMICS, S.A. (ES) 2018-03-06 US disclosed
US-9790196-B2 Lysine demethylase inhibitors for diseases and disorders associated with Flaviviridae ORYZON GENOMICS S.A. (ES) 2017-10-17 US disclosed
US-20170209432-A1 LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE OR LYMPHOPROLIFERATIVE DISEASES OR DISORDERS ORYZON GENOMICS SA (ES) 2017-07-27 US disclosed
US-20160081947-A1 SELECTIVE LSD1 AND DUAL LSD1/MAO-B INHIBITORS FOR MODULATING DISEASES ASSOCIATED WITH ALTERATIONS IN PROTEIN CONFORMATION ORYZON GENOMICS S.A. (ES) 2016-03-24 US disclosed
US-20150232436-A1 LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE DISORDERS ORYZON GENOMICS S.A. (ES) 2015-08-20 US disclosed
US-20140329833-A1 LYSINE DEMETHYLASE INHIBITORS FOR INFLAMMATORY DISEASES OR CONDITIONS ORYZON GENOMICS, S.A (ES) 2014-11-06 US disclosed
US-20140296255-A1 LYSINE DEMETHYLASE INHIBITORS FOR THROMBOSIS AND CARDIOVASCULAR DISEASES ORYZONG GENOMICS, S.A. (ES) 2014-10-02 US disclosed
US-20140256742-A1 LYSINE DEMETHYLASE INHIBITORS FOR DISEASES AND DISORDERS ASSOCIATED WITH FLAVIVIRIDAE ORYZON GENOMICS S.A. (ES) 2014-09-11 US disclosed
US-20140163041-A1 LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE OR LYMPHOPROLIFERATIVE DISEASES OR DISORDERS ORYZON GENOMICS S.A. (ES) 2014-06-12 US disclosed
US-20130303545-A1 CYCLOPROPYLAMINE DERIVATIVES USEFUL AS LSD1 INHIBITORS ORYZON GENOMICS S.A. (ES) 2013-11-14 US disclosed
WO-2012107499-A1 LYSINE DEMETHYLASE INHIBITORS FOR MYELOPROLIFERATIVE OR LYMPHOPROLIFERATIVE DISEASES OR DISORDERS ORYZON GENOMICS S.A. (ES) 2012-08-16 WO disclosed
WO-2012072713-A2 LYSINE DEMETHYLASE INHIBITORS FOR DISEASES AND DISORDERS ASSOCIATED WITH FLAVIVIRIDAE ORYZON GENOMICS, S.A. (ES) 2012-06-07 WO disclosed
WO-2012042042-A1 SELECTIVE LSD1 AND DUAL LSD1/MAO-B INHIBITORS FOR MODULATING DISEASES ASSOCIATED WITH ALTERATIONS IN PROTEIN CONFORMATION ORYZON GENOMICS S.A. (ES) 2012-04-05 WO disclosed