Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | LGALS1 | P09382 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NAAA | Q02083 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323460 | 0.86 | NAAA (0.48) | DNM1MEN1KMT2ALGALS1NAAA | |
| SCHEMBL8322672 | 0.86 | DNM1 (0.37) | DNM1MEN1KMT2AMAPTLGALS1 | |
| SCHEMBL8323458 | 0.82 | DNM1 (0.42) | DNM1MEN1KMT2ALGALS1NAAA | |
| SCHEMBL25204410 | 0.81 | MAPT (0.35) | DNM1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL9547380 | 0.81 | KDM4E (0.44) | KDM4EALDH1A1MAPK1 | |
| SCHEMBL1387314 | 0.80 | DNM1 (0.55) | DNM1MAPTLGALS1ALDH1A1ACKR3 | |
| SCHEMBL9547373 | 0.79 | MAPT (0.33) | DNM1MEN1KMT2AMAPT | |
| SCHEMBL14436497 | 0.79 | MAPT (0.33) | DNM1MEN1KMT2AMAPT | |
| SCHEMBL7778641 | 0.78 | CA12 (0.37) | DNM1MEN1KMT2AMAPTKDM4E | |
| SCHEMBL8809201 | 0.77 | DNM1 (0.71) | DNM1MEN1KMT2AMAPTNAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733045-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015952-A1 | 4,6-DIANILINO-PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS TYROSINE KINASE INHIBITORS | ZENECA LIMITED (GB) | 1995-06-15 | — | — | WO | disclosed |